Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity

Janice Endsley, Alison Hogg, Lis J. Shell, Martin McAulay, Tracey Coffey, Chris Howard, Charles F. Capinos Scherer, W. Ray Waters, Brian Nonnecke, D. Mark Estes, Bernardo Villarreal-Ramos

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The effector mechanisms used by CD4+ T cells to control mycobacteria differ between humans and rodent models of TB and should be investigated in additional animal models. In these studies, the bovine model was used to characterize the mycobactericidal CD4+ T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG). Antigenic stimulation of peripheral blood CD4+ T cells from BCG-vaccinated cattle enhanced expression of perforin and IFNγ in cells expressing a CD45RA-CD45RO+CD62L+ cell surface phenotype, enhanced transcription of granulysin, IFNγ, perforin, IL-4, IL-13, and IL-21, and enhanced anti-mycobacterial activity of CD4+ T cells against BCG-infected macrophages.

Original languageEnglish (US)
Pages (from-to)8384-8394
Number of pages11
JournalVaccine
Volume25
Issue number50
DOIs
StatePublished - Dec 5 2007

Fingerprint

Mycobacterium bovis
Bacillus
biomarkers
Vaccination
T-lymphocytes
Biomarkers
vaccination
T-Lymphocytes
Perforin
Interleukin-13
cattle
Mycobacterium
interleukin-4
Interleukin-4
Rodentia
macrophages
rodents
Animal Models
transcription (genetics)
animal models

Keywords

  • CD4 T cells
  • Cytotoxicity
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity. / Endsley, Janice; Hogg, Alison; Shell, Lis J.; McAulay, Martin; Coffey, Tracey; Howard, Chris; Capinos Scherer, Charles F.; Waters, W. Ray; Nonnecke, Brian; Estes, D. Mark; Villarreal-Ramos, Bernardo.

In: Vaccine, Vol. 25, No. 50, 05.12.2007, p. 8384-8394.

Research output: Contribution to journalArticle

Endsley, J, Hogg, A, Shell, LJ, McAulay, M, Coffey, T, Howard, C, Capinos Scherer, CF, Waters, WR, Nonnecke, B, Estes, DM & Villarreal-Ramos, B 2007, 'Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity', Vaccine, vol. 25, no. 50, pp. 8384-8394. https://doi.org/10.1016/j.vaccine.2007.10.011
Endsley, Janice ; Hogg, Alison ; Shell, Lis J. ; McAulay, Martin ; Coffey, Tracey ; Howard, Chris ; Capinos Scherer, Charles F. ; Waters, W. Ray ; Nonnecke, Brian ; Estes, D. Mark ; Villarreal-Ramos, Bernardo. / Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity. In: Vaccine. 2007 ; Vol. 25, No. 50. pp. 8384-8394.
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