Mycobacterium tuberculosis-specific CD8+T cell recall in convalescing TB subjects with HIV co-infection

Asiko Ongaya, Matthew B. Huante, Paul Mwangi, Philip H. Keiser, Evans Amukoye, Janice J. Endsley

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Memory T cell populations recover following phase I chemotherapy for tuberculosis (TB) and augment the effectiveness of antibiotics during the continuation phase of treatment. For those with human immunodeficiency virus (HIV), the CD8+T cells may have an especially important role in host defense to Mycobacterium tuberculosis (M.tb) as CD4+T cell function and/or numbers decline. Here we performed a preliminary study to investigate the impact of HIV infection status on CD8+T cell effector function during the convalescent TB period. Peripheral blood samples from convalescent HIV+ and HIV- TB subjects were used to determine CD4 +T cell count and monitor antigen-specific CD8+ T cell activation of effector function (lymphoproliferation, IFN-γ, granulysin) in response to M.tb antigen. Our preliminary results suggest that HIV co-infection is associated with moderate suppression of the M.tb-specific memory CD8+T cell compartment in many subjects convalescent for TB. Interestingly, highly activated CD8+T cells were observed in recall experiments using peripheral blood from several HIV+ subjects that had low (<200 cells/mm3) CD4+T cell counts. Further investigation may provide important information for development of novel approaches to target M.tb-specific CD8+T cell memory to protect against TB in HIV-endemic regions.

Original languageEnglish (US)
Pages (from-to)S60-S65
JournalTuberculosis
Volume93
Issue numberSUPPL.
DOIs
StatePublished - Dec 1 2013

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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