Mycoses of the breast: Diagnosis by fine‐needle aspiration

Charles Farmer, Michael W. Stanley, Ricardo H. Bardales, Sohelia Korourian, Hememdra Shah, Robert Bradsher, Vicki Klimberg

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Fungal infections of the breast are unusual and may clinically mimic carcinoma. When studied by fine‐needle aspiration (FNA), such masses may yield necrosis, granulomatous inflammation, reactive histiocytes, and atypical epithelial cells. Cohesive groups of atypical epithelial cells featured nuclear enlargement and overlapping, as well as prominent nucleoli. the organisms may be widely scattered, so that careful evaluation was required for their identification. in concert with provocative clinical findings, these features may lead to an erroneous diagnosis of malignancy. We describe three women with mycotic masses of the breast initially studied by FNA. the first patient presented at age 31 with a large, firm breast mass, chest wall extension, and radiographic evidence of vertebral bone involvement. FNA was requested to confirm the clinical diagnosis of advanced breast carcinoma. in addition to the atypia described above, the smears showed yeast forms indicative of blastomycosis surrounded by neutrophils. She remains well, following antifungal treatment. the second case of Blastomycosis was diagnosed by FNA of a breast mass in a 64‐yr‐old woman, who also responded to treatment. the third patient's preoperative needle aspiration showed granulomas, but no organisms were identified, even with special stains; silver stains of surgically excised tissue showed histoplasmosis.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalDiagnostic Cytopathology
Volume12
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Mycoses
Breast
Blastomycosis
Coloring Agents
Epithelial Cells
Histoplasmosis
Histiocytes
Thoracic Wall
Granuloma
Silver
Needles
Neutrophils
Necrosis
Yeasts
Breast Neoplasms
Inflammation
Carcinoma
Bone and Bones
Therapeutics
Neoplasms

Keywords

  • Blastomycosis
  • Breast
  • Cytology
  • Fine‐needle aspiration
  • Fungi
  • Histoplasmosis
  • Mycoses

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Farmer, C., Stanley, M. W., Bardales, R. H., Korourian, S., Shah, H., Bradsher, R., & Klimberg, V. (1995). Mycoses of the breast: Diagnosis by fine‐needle aspiration. Diagnostic Cytopathology, 12(1), 51-55. https://doi.org/10.1002/dc.2840120112

Mycoses of the breast : Diagnosis by fine‐needle aspiration. / Farmer, Charles; Stanley, Michael W.; Bardales, Ricardo H.; Korourian, Sohelia; Shah, Hememdra; Bradsher, Robert; Klimberg, Vicki.

In: Diagnostic Cytopathology, Vol. 12, No. 1, 1995, p. 51-55.

Research output: Contribution to journalArticle

Farmer, C, Stanley, MW, Bardales, RH, Korourian, S, Shah, H, Bradsher, R & Klimberg, V 1995, 'Mycoses of the breast: Diagnosis by fine‐needle aspiration', Diagnostic Cytopathology, vol. 12, no. 1, pp. 51-55. https://doi.org/10.1002/dc.2840120112
Farmer C, Stanley MW, Bardales RH, Korourian S, Shah H, Bradsher R et al. Mycoses of the breast: Diagnosis by fine‐needle aspiration. Diagnostic Cytopathology. 1995;12(1):51-55. https://doi.org/10.1002/dc.2840120112
Farmer, Charles ; Stanley, Michael W. ; Bardales, Ricardo H. ; Korourian, Sohelia ; Shah, Hememdra ; Bradsher, Robert ; Klimberg, Vicki. / Mycoses of the breast : Diagnosis by fine‐needle aspiration. In: Diagnostic Cytopathology. 1995 ; Vol. 12, No. 1. pp. 51-55.
@article{8c006cbd9715476cad574e88ffb66329,
title = "Mycoses of the breast: Diagnosis by fine‐needle aspiration",
abstract = "Fungal infections of the breast are unusual and may clinically mimic carcinoma. When studied by fine‐needle aspiration (FNA), such masses may yield necrosis, granulomatous inflammation, reactive histiocytes, and atypical epithelial cells. Cohesive groups of atypical epithelial cells featured nuclear enlargement and overlapping, as well as prominent nucleoli. the organisms may be widely scattered, so that careful evaluation was required for their identification. in concert with provocative clinical findings, these features may lead to an erroneous diagnosis of malignancy. We describe three women with mycotic masses of the breast initially studied by FNA. the first patient presented at age 31 with a large, firm breast mass, chest wall extension, and radiographic evidence of vertebral bone involvement. FNA was requested to confirm the clinical diagnosis of advanced breast carcinoma. in addition to the atypia described above, the smears showed yeast forms indicative of blastomycosis surrounded by neutrophils. She remains well, following antifungal treatment. the second case of Blastomycosis was diagnosed by FNA of a breast mass in a 64‐yr‐old woman, who also responded to treatment. the third patient's preoperative needle aspiration showed granulomas, but no organisms were identified, even with special stains; silver stains of surgically excised tissue showed histoplasmosis.",
keywords = "Blastomycosis, Breast, Cytology, Fine‐needle aspiration, Fungi, Histoplasmosis, Mycoses",
author = "Charles Farmer and Stanley, {Michael W.} and Bardales, {Ricardo H.} and Sohelia Korourian and Hememdra Shah and Robert Bradsher and Vicki Klimberg",
year = "1995",
doi = "10.1002/dc.2840120112",
language = "English (US)",
volume = "12",
pages = "51--55",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Mycoses of the breast

T2 - Diagnosis by fine‐needle aspiration

AU - Farmer, Charles

AU - Stanley, Michael W.

AU - Bardales, Ricardo H.

AU - Korourian, Sohelia

AU - Shah, Hememdra

AU - Bradsher, Robert

AU - Klimberg, Vicki

PY - 1995

Y1 - 1995

N2 - Fungal infections of the breast are unusual and may clinically mimic carcinoma. When studied by fine‐needle aspiration (FNA), such masses may yield necrosis, granulomatous inflammation, reactive histiocytes, and atypical epithelial cells. Cohesive groups of atypical epithelial cells featured nuclear enlargement and overlapping, as well as prominent nucleoli. the organisms may be widely scattered, so that careful evaluation was required for their identification. in concert with provocative clinical findings, these features may lead to an erroneous diagnosis of malignancy. We describe three women with mycotic masses of the breast initially studied by FNA. the first patient presented at age 31 with a large, firm breast mass, chest wall extension, and radiographic evidence of vertebral bone involvement. FNA was requested to confirm the clinical diagnosis of advanced breast carcinoma. in addition to the atypia described above, the smears showed yeast forms indicative of blastomycosis surrounded by neutrophils. She remains well, following antifungal treatment. the second case of Blastomycosis was diagnosed by FNA of a breast mass in a 64‐yr‐old woman, who also responded to treatment. the third patient's preoperative needle aspiration showed granulomas, but no organisms were identified, even with special stains; silver stains of surgically excised tissue showed histoplasmosis.

AB - Fungal infections of the breast are unusual and may clinically mimic carcinoma. When studied by fine‐needle aspiration (FNA), such masses may yield necrosis, granulomatous inflammation, reactive histiocytes, and atypical epithelial cells. Cohesive groups of atypical epithelial cells featured nuclear enlargement and overlapping, as well as prominent nucleoli. the organisms may be widely scattered, so that careful evaluation was required for their identification. in concert with provocative clinical findings, these features may lead to an erroneous diagnosis of malignancy. We describe three women with mycotic masses of the breast initially studied by FNA. the first patient presented at age 31 with a large, firm breast mass, chest wall extension, and radiographic evidence of vertebral bone involvement. FNA was requested to confirm the clinical diagnosis of advanced breast carcinoma. in addition to the atypia described above, the smears showed yeast forms indicative of blastomycosis surrounded by neutrophils. She remains well, following antifungal treatment. the second case of Blastomycosis was diagnosed by FNA of a breast mass in a 64‐yr‐old woman, who also responded to treatment. the third patient's preoperative needle aspiration showed granulomas, but no organisms were identified, even with special stains; silver stains of surgically excised tissue showed histoplasmosis.

KW - Blastomycosis

KW - Breast

KW - Cytology

KW - Fine‐needle aspiration

KW - Fungi

KW - Histoplasmosis

KW - Mycoses

UR - http://www.scopus.com/inward/record.url?scp=0028815685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028815685&partnerID=8YFLogxK

U2 - 10.1002/dc.2840120112

DO - 10.1002/dc.2840120112

M3 - Article

C2 - 7789247

AN - SCOPUS:0028815685

VL - 12

SP - 51

EP - 55

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

IS - 1

ER -