Myocardial depression in hyperdynamic endotoxemia

H. J. Lubbesmeyer, J. L. Theissen, S. Doty, R. Kimura, L. Traber, D. N. Herndon, D. L. Traber

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The presence of myocardial depression is difficult to assess in most animal models of septic shock caused by hypovolemia. We studied endotoxemia in fluid-resuscitated conscious sheep. They underwent chronic instrumentation with pulmonary artery, arterial and left atrial catheters. After 1 week of recovery, 1.5 μg/kg of endotoxin (LPS) was administered intravenously over a period of 30 min. One group of nine sheep stayed on baseline fluids (2 ml/kg/h of Ringer's lactate), while a second group (n = 6) was resuscitated with 7 ml/kg/h Ringer's lactate solution over the 24-h study period. Both groups were compared with controls. Eight hours after LPS, left ventricular stroke work index was depressed in both groups. In the group resuscitated with 7 ml/kg Ringer's lactate this depression associated with a normal left atrial pressure and a constant peripheral resistance indicated a shift in the Starling work curve downward and to the right evidencing myocardial depression.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalCirculatory Shock
Issue number2
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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