Myocardial depression in hyperdynamic endotoxemia

H. J. Lubbesmeyer, J. L. Theissen, S. Doty, R. Kimura, L. Traber, David Herndon, D. L. Traber

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The presence of myocardial depression is difficult to assess in most animal models of septic shock caused by hypovolemia. We studied endotoxemia in fluid-resuscitated conscious sheep. They underwent chronic instrumentation with pulmonary artery, arterial and left atrial catheters. After 1 week of recovery, 1.5 μg/kg of endotoxin (LPS) was administered intravenously over a period of 30 min. One group of nine sheep stayed on baseline fluids (2 ml/kg/h of Ringer's lactate), while a second group (n = 6) was resuscitated with 7 ml/kg/h Ringer's lactate solution over the 24-h study period. Both groups were compared with controls. Eight hours after LPS, left ventricular stroke work index was depressed in both groups. In the group resuscitated with 7 ml/kg Ringer's lactate this depression associated with a normal left atrial pressure and a constant peripheral resistance indicated a shift in the Starling work curve downward and to the right evidencing myocardial depression.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalCirculatory Shock
Volume26
Issue number2
StatePublished - 1988

Fingerprint

Endotoxemia
Sheep
Starlings
Hypovolemia
Atrial Pressure
Septic Shock
Endotoxins
Vascular Resistance
Pulmonary Artery
Catheters
Animal Models
Stroke
Ringer's lactate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lubbesmeyer, H. J., Theissen, J. L., Doty, S., Kimura, R., Traber, L., Herndon, D., & Traber, D. L. (1988). Myocardial depression in hyperdynamic endotoxemia. Circulatory Shock, 26(2), 139-146.

Myocardial depression in hyperdynamic endotoxemia. / Lubbesmeyer, H. J.; Theissen, J. L.; Doty, S.; Kimura, R.; Traber, L.; Herndon, David; Traber, D. L.

In: Circulatory Shock, Vol. 26, No. 2, 1988, p. 139-146.

Research output: Contribution to journalArticle

Lubbesmeyer, HJ, Theissen, JL, Doty, S, Kimura, R, Traber, L, Herndon, D & Traber, DL 1988, 'Myocardial depression in hyperdynamic endotoxemia', Circulatory Shock, vol. 26, no. 2, pp. 139-146.
Lubbesmeyer HJ, Theissen JL, Doty S, Kimura R, Traber L, Herndon D et al. Myocardial depression in hyperdynamic endotoxemia. Circulatory Shock. 1988;26(2):139-146.
Lubbesmeyer, H. J. ; Theissen, J. L. ; Doty, S. ; Kimura, R. ; Traber, L. ; Herndon, David ; Traber, D. L. / Myocardial depression in hyperdynamic endotoxemia. In: Circulatory Shock. 1988 ; Vol. 26, No. 2. pp. 139-146.
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