Myocardial expression of a constitutively active α(1B)-adrenergic receptor in transgenic mice induces cardiac hypertrophy

C. A. Milano, P. C. Dolber, H. A. Rockman, R. A. Bond, M. E. Venable, L. F. Allen, R. J. Lefkowitz

Research output: Contribution to journalArticlepeer-review

330 Scopus citations

Abstract

Transgenic mice were generated by using the α-myosin heavy chain promoter coupled to the coding sequence of a constitutively active mutant α(1B)- adrenergic receptor (AR). These transgenic animals demonstrated cardiac- specific expression of this α1-AR with resultant activation of phospholipase C as shown by increased myocardial diacylglycerol content. A phenotype consistent with cardiac hypertrophy developed in adult transgenic mice with increased heart/body weight ratios, myocyte cross-sectional areas, and ventricular atrial natriuretic factor mRNA levels relative to nontransgenic controls. These transgenic animals may provide insight into the biochemical triggers that induce hypertrophy in cardiac disease and serve as a convenient experimental model for studies of this condition.

Original languageEnglish (US)
Pages (from-to)10109-10113
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number21
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • catecholamines
  • phospholipase C

ASJC Scopus subject areas

  • General

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