Myocardial expression of a constitutively active α(1B)-adrenergic receptor in transgenic mice induces cardiac hypertrophy

C. A. Milano, P. C. Dolber, H. A. Rockman, R. A. Bond, M. E. Venable, L. F. Allen, R. J. Lefkowitz

    Research output: Contribution to journalArticle

    318 Scopus citations

    Abstract

    Transgenic mice were generated by using the α-myosin heavy chain promoter coupled to the coding sequence of a constitutively active mutant α(1B)- adrenergic receptor (AR). These transgenic animals demonstrated cardiac- specific expression of this α1-AR with resultant activation of phospholipase C as shown by increased myocardial diacylglycerol content. A phenotype consistent with cardiac hypertrophy developed in adult transgenic mice with increased heart/body weight ratios, myocyte cross-sectional areas, and ventricular atrial natriuretic factor mRNA levels relative to nontransgenic controls. These transgenic animals may provide insight into the biochemical triggers that induce hypertrophy in cardiac disease and serve as a convenient experimental model for studies of this condition.

    Original languageEnglish (US)
    Pages (from-to)10109-10113
    Number of pages5
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume91
    Issue number21
    DOIs
    StatePublished - Oct 25 1994

    Keywords

    • catecholamines
    • phospholipase C

    ASJC Scopus subject areas

    • General

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