Myocardial infarct size: Clinicopathologic agreement and discordance

Paul J. Boor, Edward S. Reynolds

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An accurate postmortem method of planimetrically estimating the extent of myocardial infarction was employed in 16 cases. Delineation of necrotic myocardium was enhanced by a macroscopic staining technique, which utilizes a tetrazolium dye. Comparison of infarct size with peak serum creatine phosphokinase levels showed a general correlation between the two that was not statistically significant. Two markedly disparate cases serve to emphasize the need for clinical awareness of the temporal relationship between myocardial infarction and creatinine phosphokinase analysis as well as the possiblity of other anatomic sources of elevation of serum enzyme levels. Comparison of infarct sizes in cardiogenic shock and nonshock patients confirms the existence of a significant relationship between a larger myocardial infarct and shock. However, the data from several patients in the group again emphasize the possibility of maintaining a reasonable blood pressure in the face of a massive myocardial infarction or, more importantly, of manifesting "cardiogenic" shock when only a small amount of left ventricular damage has been sustained. The latter possiblity may be related to other anatomic events, e.g., bowel infarction, hemorrhage, or possibly right ventricular ischemia, infarction, or dysfunction.

Original languageEnglish (US)
Pages (from-to)685-695
Number of pages11
JournalHuman Pathology
Volume8
Issue number6
DOIs
StatePublished - 1977
Externally publishedYes

Fingerprint

Myocardial Infarction
Cardiogenic Shock
Infarction
Creatine Kinase
Serum
Shock
Creatinine
Myocardium
Coloring Agents
Phosphotransferases
Ischemia
Staining and Labeling
Hemorrhage
Blood Pressure
Enzymes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Myocardial infarct size : Clinicopathologic agreement and discordance. / Boor, Paul J.; Reynolds, Edward S.

In: Human Pathology, Vol. 8, No. 6, 1977, p. 685-695.

Research output: Contribution to journalArticle

Boor, Paul J. ; Reynolds, Edward S. / Myocardial infarct size : Clinicopathologic agreement and discordance. In: Human Pathology. 1977 ; Vol. 8, No. 6. pp. 685-695.
@article{c6c72f9a39bb4365bd017aa9935a0de0,
title = "Myocardial infarct size: Clinicopathologic agreement and discordance",
abstract = "An accurate postmortem method of planimetrically estimating the extent of myocardial infarction was employed in 16 cases. Delineation of necrotic myocardium was enhanced by a macroscopic staining technique, which utilizes a tetrazolium dye. Comparison of infarct size with peak serum creatine phosphokinase levels showed a general correlation between the two that was not statistically significant. Two markedly disparate cases serve to emphasize the need for clinical awareness of the temporal relationship between myocardial infarction and creatinine phosphokinase analysis as well as the possiblity of other anatomic sources of elevation of serum enzyme levels. Comparison of infarct sizes in cardiogenic shock and nonshock patients confirms the existence of a significant relationship between a larger myocardial infarct and shock. However, the data from several patients in the group again emphasize the possibility of maintaining a reasonable blood pressure in the face of a massive myocardial infarction or, more importantly, of manifesting {"}cardiogenic{"} shock when only a small amount of left ventricular damage has been sustained. The latter possiblity may be related to other anatomic events, e.g., bowel infarction, hemorrhage, or possibly right ventricular ischemia, infarction, or dysfunction.",
author = "Boor, {Paul J.} and Reynolds, {Edward S.}",
year = "1977",
doi = "10.1016/S0046-8177(77)80097-X",
language = "English (US)",
volume = "8",
pages = "685--695",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Myocardial infarct size

T2 - Clinicopathologic agreement and discordance

AU - Boor, Paul J.

AU - Reynolds, Edward S.

PY - 1977

Y1 - 1977

N2 - An accurate postmortem method of planimetrically estimating the extent of myocardial infarction was employed in 16 cases. Delineation of necrotic myocardium was enhanced by a macroscopic staining technique, which utilizes a tetrazolium dye. Comparison of infarct size with peak serum creatine phosphokinase levels showed a general correlation between the two that was not statistically significant. Two markedly disparate cases serve to emphasize the need for clinical awareness of the temporal relationship between myocardial infarction and creatinine phosphokinase analysis as well as the possiblity of other anatomic sources of elevation of serum enzyme levels. Comparison of infarct sizes in cardiogenic shock and nonshock patients confirms the existence of a significant relationship between a larger myocardial infarct and shock. However, the data from several patients in the group again emphasize the possibility of maintaining a reasonable blood pressure in the face of a massive myocardial infarction or, more importantly, of manifesting "cardiogenic" shock when only a small amount of left ventricular damage has been sustained. The latter possiblity may be related to other anatomic events, e.g., bowel infarction, hemorrhage, or possibly right ventricular ischemia, infarction, or dysfunction.

AB - An accurate postmortem method of planimetrically estimating the extent of myocardial infarction was employed in 16 cases. Delineation of necrotic myocardium was enhanced by a macroscopic staining technique, which utilizes a tetrazolium dye. Comparison of infarct size with peak serum creatine phosphokinase levels showed a general correlation between the two that was not statistically significant. Two markedly disparate cases serve to emphasize the need for clinical awareness of the temporal relationship between myocardial infarction and creatinine phosphokinase analysis as well as the possiblity of other anatomic sources of elevation of serum enzyme levels. Comparison of infarct sizes in cardiogenic shock and nonshock patients confirms the existence of a significant relationship between a larger myocardial infarct and shock. However, the data from several patients in the group again emphasize the possibility of maintaining a reasonable blood pressure in the face of a massive myocardial infarction or, more importantly, of manifesting "cardiogenic" shock when only a small amount of left ventricular damage has been sustained. The latter possiblity may be related to other anatomic events, e.g., bowel infarction, hemorrhage, or possibly right ventricular ischemia, infarction, or dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=0017724811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017724811&partnerID=8YFLogxK

U2 - 10.1016/S0046-8177(77)80097-X

DO - 10.1016/S0046-8177(77)80097-X

M3 - Article

C2 - 72721

AN - SCOPUS:0017724811

VL - 8

SP - 685

EP - 695

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 6

ER -