Myoelectric activity and absorptive capacity of rat small intestinal isografts

Gordon L. Telford, Michael A. Nemeth, Sushil K. Sarna, M. Scott Harris, Krishnamurthy Ramaswamy, Wolfgang H. Schraut, Kenneth K W Lee, Christopher P. Johnson, Susan Walgenbach-Telford

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 ± 0.3/hr in controls and 1.8 ± 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 ± 1.3/hr in controls and 3.2 ± 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 ± 3% of the time in controls and 59 ± 7% of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 ± 6 cm for controls and 51 ± 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.

Original languageEnglish (US)
Pages (from-to)1082-1087
Number of pages6
JournalDigestive Diseases and Sciences
Volume41
Issue number6
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Isografts
Duodenum
Migrating Myoelectric Complexes
Transplants
Inbred Lew Rats
Sucrase
Intestinal Absorption
Microvilli
Electrolytes
Intestines
Electrodes
Transplantation
Glucose

Keywords

  • Gastrointestinal motility
  • Intestinal absorption
  • Small intestine
  • Transplantation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Telford, G. L., Nemeth, M. A., Sarna, S. K., Harris, M. S., Ramaswamy, K., Schraut, W. H., ... Walgenbach-Telford, S. (1996). Myoelectric activity and absorptive capacity of rat small intestinal isografts. Digestive Diseases and Sciences, 41(6), 1082-1087. https://doi.org/10.1007/BF02088223

Myoelectric activity and absorptive capacity of rat small intestinal isografts. / Telford, Gordon L.; Nemeth, Michael A.; Sarna, Sushil K.; Harris, M. Scott; Ramaswamy, Krishnamurthy; Schraut, Wolfgang H.; Lee, Kenneth K W; Johnson, Christopher P.; Walgenbach-Telford, Susan.

In: Digestive Diseases and Sciences, Vol. 41, No. 6, 1996, p. 1082-1087.

Research output: Contribution to journalArticle

Telford, GL, Nemeth, MA, Sarna, SK, Harris, MS, Ramaswamy, K, Schraut, WH, Lee, KKW, Johnson, CP & Walgenbach-Telford, S 1996, 'Myoelectric activity and absorptive capacity of rat small intestinal isografts', Digestive Diseases and Sciences, vol. 41, no. 6, pp. 1082-1087. https://doi.org/10.1007/BF02088223
Telford GL, Nemeth MA, Sarna SK, Harris MS, Ramaswamy K, Schraut WH et al. Myoelectric activity and absorptive capacity of rat small intestinal isografts. Digestive Diseases and Sciences. 1996;41(6):1082-1087. https://doi.org/10.1007/BF02088223
Telford, Gordon L. ; Nemeth, Michael A. ; Sarna, Sushil K. ; Harris, M. Scott ; Ramaswamy, Krishnamurthy ; Schraut, Wolfgang H. ; Lee, Kenneth K W ; Johnson, Christopher P. ; Walgenbach-Telford, Susan. / Myoelectric activity and absorptive capacity of rat small intestinal isografts. In: Digestive Diseases and Sciences. 1996 ; Vol. 41, No. 6. pp. 1082-1087.
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abstract = "The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 ± 0.3/hr in controls and 1.8 ± 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 ± 1.3/hr in controls and 3.2 ± 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 ± 3{\%} of the time in controls and 59 ± 7{\%} of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40{\%} decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 ± 6 cm for controls and 51 ± 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.",
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