TY - JOUR
T1 - Myoelectric activity and absorptive capacity of rat small intestinal isografts
AU - Telford, Gordon L.
AU - Nemeth, Michael A.
AU - Sarna, Sushil K.
AU - Harris, M. Scott
AU - Ramaswamy, Krishnamurthy
AU - Schraut, Wolfgang H.
AU - Lee, Kenneth K.W.
AU - Johnson, Christopher P.
AU - Walgenbach-Telford, Susan
PY - 1996
Y1 - 1996
N2 - The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 ± 0.3/hr in controls and 1.8 ± 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 ± 1.3/hr in controls and 3.2 ± 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 ± 3% of the time in controls and 59 ± 7% of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 ± 6 cm for controls and 51 ± 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.
AB - The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 ± 0.3/hr in controls and 1.8 ± 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 ± 1.3/hr in controls and 3.2 ± 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 ± 3% of the time in controls and 59 ± 7% of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 ± 6 cm for controls and 51 ± 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.
KW - Gastrointestinal motility
KW - Intestinal absorption
KW - Small intestine
KW - Transplantation
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U2 - 10.1007/BF02088223
DO - 10.1007/BF02088223
M3 - Article
C2 - 8654138
AN - SCOPUS:0029679913
SN - 0163-2116
VL - 41
SP - 1082
EP - 1087
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 6
ER -