Myoelectric activity and absorptive capacity of rat small intestinal isografts

Gordon L. Telford; Michael A. Nemeth; Sushil K. Sarna; M. Scott Harris; Krishnamurthy Ramaswamy; Wolfgang H. Schraut; Kenneth K.W. Lee; Christopher P. Johnson; Susan Walgenbach-Telford

doi:10.1007/BF02088223

Myoelectric activity and absorptive capacity of rat small intestinal isografts

Gordon L. Telford, Michael A. Nemeth, Sushil K. Sarna, M. Scott Harris, Krishnamurthy Ramaswamy, Wolfgang H. Schraut, Kenneth K.W. Lee, Christopher P. Johnson, Susan Walgenbach-Telford

Internal Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 ± 0.3/hr in controls and 1.8 ± 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 ± 1.3/hr in controls and 3.2 ± 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 ± 3% of the time in controls and 59 ± 7% of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 ± 6 cm for controls and 51 ± 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.

Original language	English (US)
Pages (from-to)	1082-1087
Number of pages	6
Journal	Digestive Diseases and Sciences
Volume	41
Issue number	6
DOIs	https://doi.org/10.1007/BF02088223
State	Published - 1996

Keywords

Gastrointestinal motility
Intestinal absorption
Small intestine
Transplantation

ASJC Scopus subject areas

Physiology
Gastroenterology

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10.1007/BF02088223

Cite this

@article{30de3d38a81b4a04a509a851bec920b8,

title = "Myoelectric activity and absorptive capacity of rat small intestinal isografts",

abstract = "The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 ± 0.3/hr in controls and 1.8 ± 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 ± 1.3/hr in controls and 3.2 ± 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 ± 3% of the time in controls and 59 ± 7% of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 ± 6 cm for controls and 51 ± 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.",

keywords = "Gastrointestinal motility, Intestinal absorption, Small intestine, Transplantation",

author = "Telford, {Gordon L.} and Nemeth, {Michael A.} and Sarna, {Sushil K.} and Harris, {M. Scott} and Krishnamurthy Ramaswamy and Schraut, {Wolfgang H.} and Lee, {Kenneth K.W.} and Johnson, {Christopher P.} and Susan Walgenbach-Telford",

year = "1996",

doi = "10.1007/BF02088223",

language = "English (US)",

volume = "41",

pages = "1082--1087",

journal = "Digestive Diseases and Sciences",

issn = "0163-2116",

publisher = "Springer New York",

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T1 - Myoelectric activity and absorptive capacity of rat small intestinal isografts

AU - Telford, Gordon L.

AU - Nemeth, Michael A.

AU - Sarna, Sushil K.

AU - Harris, M. Scott

AU - Ramaswamy, Krishnamurthy

AU - Schraut, Wolfgang H.

AU - Lee, Kenneth K.W.

AU - Johnson, Christopher P.

AU - Walgenbach-Telford, Susan

PY - 1996

Y1 - 1996

N2 - The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 ± 0.3/hr in controls and 1.8 ± 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 ± 1.3/hr in controls and 3.2 ± 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 ± 3% of the time in controls and 59 ± 7% of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 ± 6 cm for controls and 51 ± 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.

AB - The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3 ± 0.3/hr in controls and 1.8 ± 0.4/hr in transplants (P < 0.05). MMC frequency in the jejunoileum was 5.1 ± 1.3/hr in controls and 3.2 ± 0.9/hr in transplants (P > 0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80 ± 3% of the time in controls and 59 ± 7% of the time in transplant rats (P < 0.05). Absorption in the transplanted jejunoileum demonstrated a 35-40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103 ± 6 cm for controls and 51 ± 3 cm for transplant rats (P < 0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.

KW - Gastrointestinal motility

KW - Intestinal absorption

KW - Small intestine

KW - Transplantation

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JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 6

ER -

Myoelectric activity and absorptive capacity of rat small intestinal isografts

Abstract

Keywords

ASJC Scopus subject areas

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