Myoelectric and contractile effects of motilin on dog small intestine in vivo

Ivan M. Lang, Sushil K. Sarna, Robert E. Condon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effects of the close intraarterial administration of motilin on intestinal myoelectric and contractile activities were examined in 37 dogs. After anesthetization or decerebration, a segment of proximal jejunum was instrumented serosally with electrodes and stain gauges. A mesenteric artery supplying a short length of this segment was cannulated for the injection of motilin and other agents. Motilin (0.03-0.3 μg) caused: (1) a series (1-5 min) of phasic contractions and electrical response activity (ERA) bursts locally; (2) a short (15-60 sec) series of phasic contractions and ERA bursts aborally followed by relaxation; and (3) a series of phasic contractions and ERA bursts whose onset migrated 3.7±1.0 cm orally. The length of orad response increased to 6.6±1.9 cm in the decerebrate dogs (P<0.01). No other tested agent, including serotonin, bethanechol, morphine, dopamine, substance P, neurotensin, somatostatin, vasoactive intestinal peptide, bombesin, pentagastrin, cholecystokinin octapeptide, prostaglandin F or leucine-enkephalin, cuased similar responses. All motilin responses were mediated by neural pathways consisting of both nicotinic and muscarinic receptors. The similarity of responses and mechanisms of action of the motilin-activated contractile response with the intrinsic mucosal reflex suggested that motilin may mediate this reflex.

Original languageEnglish (US)
Pages (from-to)1062-1072
Number of pages11
JournalDigestive Diseases and Sciences
Volume31
Issue number10
DOIs
StatePublished - Oct 1986
Externally publishedYes

Fingerprint

Motilin
Small Intestine
Dogs
Reflex
Bethanechol
Serotonin Agents
Leucine Enkephalin
Neural Pathways
Bombesin
Sincalide
Pentagastrin
Neurotensin
Mesenteric Arteries
Dinoprost
Vasoactive Intestinal Peptide
Nicotinic Receptors
Muscarinic Receptors
Jejunum
Substance P
Somatostatin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Myoelectric and contractile effects of motilin on dog small intestine in vivo. / Lang, Ivan M.; Sarna, Sushil K.; Condon, Robert E.

In: Digestive Diseases and Sciences, Vol. 31, No. 10, 10.1986, p. 1062-1072.

Research output: Contribution to journalArticle

Lang, Ivan M. ; Sarna, Sushil K. ; Condon, Robert E. / Myoelectric and contractile effects of motilin on dog small intestine in vivo. In: Digestive Diseases and Sciences. 1986 ; Vol. 31, No. 10. pp. 1062-1072.
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