Myofibroblasts. II. Intestinal subepithelial myofibroblasts

D. W. Powell, R. C. Mifflin, J. D. Valentich, S. E. Crowe, J. I. Saada, A. B. West

Research output: Contribution to journalArticle

464 Citations (Scopus)

Abstract

Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and proliferate in response to various growth factors, particularly the platelet-derived growth factor (PDGF) family, which includes PDGF-BB and stem cell factor (SCF), through expression of PDGF receptors and the SCF receptor c-kit. ISEMF have been shown to play important roles in the organogenesis of the intestine, and growth factors and cytokines secreted by these cells promote epithelial restitution and proliferation, i.e., wound repair. Their role in the fibrosis of Crohn's disease and collagenous colitis is being investigated. Through cyclooxygenase (COX)-1 and COX-2 activation, ISEMF augment intestinal ion secretion in response to certain secretagogues. By forming a subepithelial barrier to Na+ diffusion, they create a hypertonic compartment that may account for the ability of the gut to transport fluid against an adverse osmotic gradient. Through the paracrine secretion of prostaglandins and growth factors (e.g., transforming growth factor-β), ISEMF may play a role in colonic tumorigenesis and metastasis. COX-2 in polyp ISEMF may be a target for nonsteroidal anti-inflammatory drugs (NSAIDs), which would account for the regression of the neoplasms in familial adenomatous polyposis and the preventive effect of NSAIDs in the development of sporadic colon neoplasms. More investigation is needed to clarify the functions of these pleiotropic cells.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Cell Physiology
Volume277
Issue number2 46-2
StatePublished - 1999

Fingerprint

Myofibroblasts
Cyclooxygenase 2
Intercellular Signaling Peptides and Proteins
Anti-Inflammatory Agents
Proto-Oncogene Proteins c-kit
Platelet-Derived Growth Factor Receptors
Cyclooxygenase 1
Stem Cell Factor
Platelet-Derived Growth Factor
Transforming Growth Factors
Pharmaceutical Preparations
Prostaglandins
Repair
Chemical activation
Cells
Ions
Cytokines
Fluids
Intestines
Intestinal Polyps

Keywords

  • Chemoprevention
  • Cyclooxygenase
  • Electrolyte transport
  • Fibrosis
  • Immunophysiology
  • Interstitial cells of Cajal
  • Wound repair

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology
  • Physiology (medical)

Cite this

Powell, D. W., Mifflin, R. C., Valentich, J. D., Crowe, S. E., Saada, J. I., & West, A. B. (1999). Myofibroblasts. II. Intestinal subepithelial myofibroblasts. American Journal of Physiology - Cell Physiology, 277(2 46-2).

Myofibroblasts. II. Intestinal subepithelial myofibroblasts. / Powell, D. W.; Mifflin, R. C.; Valentich, J. D.; Crowe, S. E.; Saada, J. I.; West, A. B.

In: American Journal of Physiology - Cell Physiology, Vol. 277, No. 2 46-2, 1999.

Research output: Contribution to journalArticle

Powell, DW, Mifflin, RC, Valentich, JD, Crowe, SE, Saada, JI & West, AB 1999, 'Myofibroblasts. II. Intestinal subepithelial myofibroblasts', American Journal of Physiology - Cell Physiology, vol. 277, no. 2 46-2.
Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. Myofibroblasts. II. Intestinal subepithelial myofibroblasts. American Journal of Physiology - Cell Physiology. 1999;277(2 46-2).
Powell, D. W. ; Mifflin, R. C. ; Valentich, J. D. ; Crowe, S. E. ; Saada, J. I. ; West, A. B. / Myofibroblasts. II. Intestinal subepithelial myofibroblasts. In: American Journal of Physiology - Cell Physiology. 1999 ; Vol. 277, No. 2 46-2.
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