Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle Hypertrophy

Christopher Fry, Tyler J. Kirby, Kate Kosmac, John J. McCarthy, Charlotte A. Peterson

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Satellite cells, the predominant stem cell population in adult skeletal muscle, are activated in response to hypertrophic stimuli and give rise to myogenic progenitor cells (MPCs) within the extracellular matrix (ECM) that surrounds myofibers. This ECM is composed largely of collagens secreted by interstitial fibrogenic cells, which influence satellite cell activity and muscle repair during hypertrophy and aging. Here we show that MPCs interact with interstitial fibrogenic cells to ensure proper ECM deposition and optimal muscle remodeling in response to hypertrophic stimuli. MPC-dependent ECM remodeling during the first week of a growth stimulus is sufficient to ensure long-term myofiber hypertrophy. MPCs secrete exosomes containing miR-206, which represses Rrbp1, a master regulator of collagen biosynthesis, in fibrogenic cells to prevent excessive ECM deposition. These findings provide insights into how skeletal stem and progenitor cells interact with other cell types to actively regulate their extracellular environments for tissue maintenance and adaptation.

Original languageEnglish (US)
Pages (from-to)56-69
Number of pages14
JournalCell Stem Cell
Volume20
Issue number1
DOIs
StatePublished - Jan 5 2017

Fingerprint

Hypertrophy
Extracellular Matrix
Skeletal Muscle
Stem Cells
Fibroblasts
Collagen
Exosomes
Muscle Cells
Maintenance
Muscles
Growth
Population

Keywords

  • collagen
  • exosomes
  • extracellular matrix
  • fibrosis
  • hypertrophy
  • microRNA
  • muscle
  • muscle progenitor cells
  • Pax7
  • satellite cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

Cite this

Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle Hypertrophy. / Fry, Christopher; Kirby, Tyler J.; Kosmac, Kate; McCarthy, John J.; Peterson, Charlotte A.

In: Cell Stem Cell, Vol. 20, No. 1, 05.01.2017, p. 56-69.

Research output: Contribution to journalArticle

Fry, Christopher ; Kirby, Tyler J. ; Kosmac, Kate ; McCarthy, John J. ; Peterson, Charlotte A. / Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle Hypertrophy. In: Cell Stem Cell. 2017 ; Vol. 20, No. 1. pp. 56-69.
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