N-(4-Hydroxyphenyl)retinamide induces apoptosis in T lymphoma and T Lymphoblastoid leukemia cells

Lee Nien L. Chan, Shuliu Zhang, Jinyi Shag, Rebekah Waikela, E. Aubrey Thompson, Teh Sheng Chan

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We demonstrate that N-(4-hydroxyphenyl)-all-trans-retinamide (4-HPR), a synthetic retinoic acid (RA) derivative, is a potent and selective inducer of apoptosis in malignant T lymphoid cells, but has little effect on normal lymphoid cells of the thymus or spleen. 4-HPR and its stereoisomer, 9-cis-4-HPR, are 50 to< 150 times more potent than 7 other retinoids in killing CEM-C7 human T lymphoblastoid leukemia cells and P1798-C7 murine T lymphoma cells. 4-HPR's apoptotic action requires the intact molecule bearing both the retinoid moiety and the hydroxyphenol ring; 4-HPR remains unmetabolized after uptake into CEM-C7 and P1798-C7 cells for up to 24 hours. We also show that glucocorticoid (GC)-resistant variants are equally susceptible to 4-HPR as are GC-sensitive cells. Thus, 4-HPR may be potentially important as a new chemotherapeutic drug for use as alternative to, or in combination with, conventional drugs for treating lymphoid malignancies.

Original languageEnglish (US)
Pages (from-to)271-280
Number of pages10
JournalLeukemia and Lymphoma
Volume25
Issue number42067
DOIs
StatePublished - Jan 1 1997

Keywords

  • 4-HPR
  • apoptosis
  • drug effect
  • lymphoid malignancies
  • retinoids

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Chan, L. N. L., Zhang, S., Shag, J., Waikela, R., Thompson, E. A., & Chan, T. S. (1997). N-(4-Hydroxyphenyl)retinamide induces apoptosis in T lymphoma and T Lymphoblastoid leukemia cells. Leukemia and Lymphoma, 25(42067), 271-280. https://doi.org/10.3109/10428199709114166