N-(4-hydroxyphenyl)retinamide prevents development of T-lymphomas in AKR/J mice

Lee Nien Lillian Chan, Shuliu Zhang, Miles Cloyd, Teh Sheng Chan

Research output: Contribution to journalArticle

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Abstract

N-(4-Hydroxyphenyl)retinamide (4-HPR), a synthetic retinoic acid derivative, has chemopreventive effects on several types of cancer. We recently showed that 4-HPR is a potent inducer of apoptosis in malignant, but not normal, T-lymphoid cells in vitro. To test 4-HPR's effect in vivo, we used the virus-induced T-lymphoma in AKR/J mice as a model system. The AKR/J mice were fed 4-HPR at 0, 1 or 2 mmole/kg diet, and the animals were monitored as to tumor development, plasma level of 4-HPR, body weight, appetite, and general health. Our results show that in a 19-week period, 4-HPR prevented T-lymphoma development by 40% and 50% of animals fed 1 and 2 mmole 4-HPR/kg diet, respectively. In the plasma, 4-HPR reached micromolar levels without causing any observable deleterious side-effects. Thus, 4-HPR is potentially useful in chemoprevention of lymphoid cancers.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalAnticancer Research
Volume17
Issue number1 A
StatePublished - 1997

Fingerprint

Fenretinide
Inbred AKR Mouse
Lymphoma
Diet
Neoplasms
Chemoprevention
Appetite
Tretinoin
Body Weight
Lymphocytes
Apoptosis
Viruses

Keywords

  • AKR/J mice
  • Chemoprevention
  • Lymphoma
  • N-(4-hydroxyphenyl)retinamide
  • Tumor development

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chan, L. N. L., Zhang, S., Cloyd, M., & Chan, T. S. (1997). N-(4-hydroxyphenyl)retinamide prevents development of T-lymphomas in AKR/J mice. Anticancer Research, 17(1 A), 499-503.

N-(4-hydroxyphenyl)retinamide prevents development of T-lymphomas in AKR/J mice. / Chan, Lee Nien Lillian; Zhang, Shuliu; Cloyd, Miles; Chan, Teh Sheng.

In: Anticancer Research, Vol. 17, No. 1 A, 1997, p. 499-503.

Research output: Contribution to journalArticle

Chan, LNL, Zhang, S, Cloyd, M & Chan, TS 1997, 'N-(4-hydroxyphenyl)retinamide prevents development of T-lymphomas in AKR/J mice', Anticancer Research, vol. 17, no. 1 A, pp. 499-503.
Chan, Lee Nien Lillian ; Zhang, Shuliu ; Cloyd, Miles ; Chan, Teh Sheng. / N-(4-hydroxyphenyl)retinamide prevents development of T-lymphomas in AKR/J mice. In: Anticancer Research. 1997 ; Vol. 17, No. 1 A. pp. 499-503.
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