N-acetyl-β-hexosaminidase

Role in the degradation of glycosaminoglycans

Jerry N. Thompson, Allen C. Stoolmiller, Reuben Matalon, Albert Dorfman

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Extracts of cultured normal human skin fibroblasts released radioactivity from a 14C-labeled heptasaccharide prepared by addition of [ 14C]N-acetylgalactosamine to the nonreducing terminus of a hexasaccharide derived from chondroitin 4-sulfate whereas fibroblast extracts from patients with Tay-Sachs and Sandhoff-Jatzkewitz diseases did not. The results suggest that N-acetyl-β-hexosaminidase A is responsible for degradation of the oligosaccharide substrate.

Original languageEnglish (US)
Pages (from-to)866-867
Number of pages2
JournalScience
Volume181
Issue number4102
StatePublished - 1973
Externally publishedYes

Fingerprint

Hexosaminidases
Glycosaminoglycans
Sandhoff Disease
Fibroblasts
Hexosaminidase A
Acetylgalactosamine
Chondroitin Sulfates
Oligosaccharides
Radioactivity
Skin

ASJC Scopus subject areas

  • General

Cite this

Thompson, J. N., Stoolmiller, A. C., Matalon, R., & Dorfman, A. (1973). N-acetyl-β-hexosaminidase: Role in the degradation of glycosaminoglycans. Science, 181(4102), 866-867.

N-acetyl-β-hexosaminidase : Role in the degradation of glycosaminoglycans. / Thompson, Jerry N.; Stoolmiller, Allen C.; Matalon, Reuben; Dorfman, Albert.

In: Science, Vol. 181, No. 4102, 1973, p. 866-867.

Research output: Contribution to journalArticle

Thompson, JN, Stoolmiller, AC, Matalon, R & Dorfman, A 1973, 'N-acetyl-β-hexosaminidase: Role in the degradation of glycosaminoglycans', Science, vol. 181, no. 4102, pp. 866-867.
Thompson JN, Stoolmiller AC, Matalon R, Dorfman A. N-acetyl-β-hexosaminidase: Role in the degradation of glycosaminoglycans. Science. 1973;181(4102):866-867.
Thompson, Jerry N. ; Stoolmiller, Allen C. ; Matalon, Reuben ; Dorfman, Albert. / N-acetyl-β-hexosaminidase : Role in the degradation of glycosaminoglycans. In: Science. 1973 ; Vol. 181, No. 4102. pp. 866-867.
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