N-acetyl-β-hexosaminidase: Role in the degradation of glycosaminoglycans

Jerry N. Thompson, Allen C. Stoolmiller, Reuben Matalon, Albert Dorfman

Research output: Contribution to journalArticle

35 Scopus citations


Extracts of cultured normal human skin fibroblasts released radioactivity from a 14C-labeled heptasaccharide prepared by addition of [ 14C]N-acetylgalactosamine to the nonreducing terminus of a hexasaccharide derived from chondroitin 4-sulfate whereas fibroblast extracts from patients with Tay-Sachs and Sandhoff-Jatzkewitz diseases did not. The results suggest that N-acetyl-β-hexosaminidase A is responsible for degradation of the oligosaccharide substrate.

Original languageEnglish (US)
Pages (from-to)866-867
Number of pages2
Issue number4102
StatePublished - Jan 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'N-acetyl-β-hexosaminidase: Role in the degradation of glycosaminoglycans'. Together they form a unique fingerprint.

  • Cite this