N-acetyl-β-hexosaminidase: Role in the degradation of glycosaminoglycans

Jerry N. Thompson, Allen C. Stoolmiller, Reuben Matalon, Albert Dorfman

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Extracts of cultured normal human skin fibroblasts released radioactivity from a 14C-labeled heptasaccharide prepared by addition of [ 14C]N-acetylgalactosamine to the nonreducing terminus of a hexasaccharide derived from chondroitin 4-sulfate whereas fibroblast extracts from patients with Tay-Sachs and Sandhoff-Jatzkewitz diseases did not. The results suggest that N-acetyl-β-hexosaminidase A is responsible for degradation of the oligosaccharide substrate.

Original languageEnglish (US)
Pages (from-to)866-867
Number of pages2
JournalScience
Volume181
Issue number4102
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • General

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