N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter

K. R.C. Prakash, Amir P. Tamiz, Gian Luca Araldi, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.

Original languageEnglish (US)
Pages (from-to)3325-3328
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number23
DOIs
StatePublished - Dec 6 1999

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this