N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter

K. R C Prakash, Amir P. Tamiz, Gian Luca Araldi, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.

Original languageEnglish (US)
Pages (from-to)3325-3328
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number23
StatePublished - Dec 6 1999

Fingerprint

Tropanes
Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Ships
Boats
Conformations
Dopamine
Serotonin
Corpus Striatum
Nerve Endings
Synaptosomes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Prakash, K. R. C., Tamiz, A. P., Araldi, G. L., Zhang, M., Johnson, K. M., & Kozikowski, A. P. (1999). N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter. Bioorganic and Medicinal Chemistry Letters, 9(23), 3325-3328.

N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter. / Prakash, K. R C; Tamiz, Amir P.; Araldi, Gian Luca; Zhang, Mei; Johnson, Kenneth M.; Kozikowski, Alan P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 23, 06.12.1999, p. 3325-3328.

Research output: Contribution to journalArticle

Prakash, KRC, Tamiz, AP, Araldi, GL, Zhang, M, Johnson, KM & Kozikowski, AP 1999, 'N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter', Bioorganic and Medicinal Chemistry Letters, vol. 9, no. 23, pp. 3325-3328.
Prakash, K. R C ; Tamiz, Amir P. ; Araldi, Gian Luca ; Zhang, Mei ; Johnson, Kenneth M. ; Kozikowski, Alan P. / N-phenylalkyl-substituted tropane analogs of boat conformation with high selectivity for the dopamine versus serotonin transporter. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 23. pp. 3325-3328.
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