N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

Zheng Yin; Yen Liang Chen; Ravinder Reddy Kondreddi; Wai Ling Chan; Gang Wang; Ru Hui Ng; Joanne Y.H. Lim; Wan Yen Lee; Duraiswamy A. Jeyaraj; Pornwaratt Niyomrattanakit; Daying Wen; Alex Chao; J. Fraser Glickman; Hans Voshol; Dieter Mueller; Carsten Spanka; Sigmar Dressler; Shahul Nilar; Subhash G. Vasudevan; Pei Yong Shi; Thomas H. Keller

doi:10.1021/jm901044z

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

Zheng Yin, Yen Liang Chen, Ravinder Reddy Kondreddi, Wai Ling Chan, Gang Wang, Ru Hui Ng, Joanne Y.H. Lim, Wan Yen Lee, Duraiswamy A. Jeyaraj, Pornwaratt Niyomrattanakit, Daying Wen, Alex Chao, J. Fraser Glickman, Hans Voshol, Dieter Mueller, Carsten Spanka, Sigmar Dressler, Shahul Nilar, Subhash G. Vasudevan, Pei Yong ShiThomas H. Keller

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.

Original language	English (US)
Pages (from-to)	7934-7937
Number of pages	4
Journal	Journal of medicinal chemistry
Volume	52
Issue number	24
DOIs	https://doi.org/10.1021/jm901044z
State	Published - Dec 24 2009

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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Yin, Z., Chen, Y. L., Kondreddi, R. R., Chan, W. L., Wang, G., Ng, R. H., Lim, J. Y. H., Lee, W. Y., Jeyaraj, D. A., Niyomrattanakit, P., Wen, D., Chao, A., Glickman, J. F., Voshol, H., Mueller, D., Spanka, C., Dressler, S., Nilar, S., Vasudevan, S. G., ... Keller, T. H. (2009). N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase. Journal of medicinal chemistry, 52(24), 7934-7937. https://doi.org/10.1021/jm901044z

Yin, Z, Chen, YL, Kondreddi, RR, Chan, WL, Wang, G, Ng, RH, Lim, JYH, Lee, WY, Jeyaraj, DA, Niyomrattanakit, P, Wen, D, Chao, A, Glickman, JF, Voshol, H, Mueller, D, Spanka, C, Dressler, S, Nilar, S, Vasudevan, SG, Shi, PY & Keller, TH 2009, 'N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase', Journal of medicinal chemistry, vol. 52, no. 24, pp. 7934-7937. https://doi.org/10.1021/jm901044z

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abstract = "A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.",

author = "Zheng Yin and Chen, {Yen Liang} and Kondreddi, {Ravinder Reddy} and Chan, {Wai Ling} and Gang Wang and Ng, {Ru Hui} and Lim, {Joanne Y.H.} and Lee, {Wan Yen} and Jeyaraj, {Duraiswamy A.} and Pornwaratt Niyomrattanakit and Daying Wen and Alex Chao and Glickman, {J. Fraser} and Hans Voshol and Dieter Mueller and Carsten Spanka and Sigmar Dressler and Shahul Nilar and Vasudevan, {Subhash G.} and Shi, {Pei Yong} and Keller, {Thomas H.}",

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AU - Yin, Zheng

AU - Chen, Yen Liang

AU - Kondreddi, Ravinder Reddy

AU - Chan, Wai Ling

AU - Wang, Gang

AU - Ng, Ru Hui

AU - Lim, Joanne Y.H.

AU - Lee, Wan Yen

AU - Jeyaraj, Duraiswamy A.

AU - Niyomrattanakit, Pornwaratt

AU - Wen, Daying

AU - Chao, Alex

AU - Glickman, J. Fraser

AU - Voshol, Hans

AU - Mueller, Dieter

AU - Spanka, Carsten

AU - Dressler, Sigmar

AU - Nilar, Shahul

AU - Vasudevan, Subhash G.

AU - Shi, Pei Yong

AU - Keller, Thomas H.

PY - 2009/12/24

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AB - A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.

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N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

Abstract

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