N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

Zheng Yin, Yen Liang Chen, Ravinder Reddy Kondreddi, Wai Ling Chan, Gang Wang, Ru Hui Ng, Joanne Y.H. Lim, Wan Yen Lee, Duraiswamy A. Jeyaraj, Pornwaratt Niyomrattanakit, Daying Wen, Alex Chao, J. Fraser Glickman, Hans Voshol, Dieter Mueller, Carsten Spanka, Sigmar Dressler, Shahul Nilar, Subhash G. Vasudevan, Pei Yong ShiThomas H. Keller

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.

Original languageEnglish (US)
Pages (from-to)7934-7937
Number of pages4
JournalJournal of Medicinal Chemistry
Volume52
Issue number24
DOIs
StatePublished - Dec 24 2009
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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  • Cite this

    Yin, Z., Chen, Y. L., Kondreddi, R. R., Chan, W. L., Wang, G., Ng, R. H., Lim, J. Y. H., Lee, W. Y., Jeyaraj, D. A., Niyomrattanakit, P., Wen, D., Chao, A., Glickman, J. F., Voshol, H., Mueller, D., Spanka, C., Dressler, S., Nilar, S., Vasudevan, S. G., ... Keller, T. H. (2009). N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase. Journal of Medicinal Chemistry, 52(24), 7934-7937. https://doi.org/10.1021/jm901044z