Nanoparticles: Augmenting tumor antigen presentation for vaccine and immunotherapy treatments of cancer

Charles B. Chesson, Andrew Zloza

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

The major goal of immunity is maintaining host survival. Toward this, immune cells recognize and eliminate targets that pose a danger. Primarily, these are external invaders (pathogens) and internal invaders (cancers). Their recognition relies on distinguishing foreign components (antigens) from self-antigens. Since cancer cells are the host's own cells that are harmfully altered, they are difficult to distinguish from normal self. Furthermore, the antigens least resembling the host are often sequestered in parts of the tumor least accessible to immune responses. Therefore, to sufficiently boost immunity, these tumor antigens must be exposed to the immune system. Toward this, nanoparticles provide an innovating means of tumor antigen presentation and are destined to become an integral part of cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)2693-2706
Number of pages14
JournalNanomedicine
Volume12
Issue number23
DOIs
StatePublished - Dec 2017
Externally publishedYes

Keywords

  • cancer
  • immunotherapy
  • nanoparticles
  • tumor antigens
  • vaccines

ASJC Scopus subject areas

  • Bioengineering
  • Development
  • Biomedical Engineering
  • General Materials Science
  • Medicine (miscellaneous)

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