Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols

Pradeep Puligundla, Chulkyoon Mok, Sanghoon Ko, Jin Liang, Neeraja Recharla

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Green tea contains numerous bioactive compounds that may provide multiple health benefits, including antioxidative, anti-inflammatory, anti-carcinogenic, anti-proliferative, anti-hypertensive, antithrombogenic and lipid-lowering effects. Most of the chemopreventive and therapeutic effects of green tea extracts have been attributed to the presence of different polyphenolic bioactives, especially catechins, in their composition. Although these polyphenolic compounds have been shown promising therapeutic effects under in vitro conditions, they met with limited efficacy in clinical settings due to various reasons such as poor oral absorption and bioavailability. Different techniques have been proposed to improve the bioavailability of green tea polyphenols. Among such strategies, nanoparticle-based delivery systems are novel and promising tools. This review is intended to discuss the advances related to improvement of in vitro and in vivo bioavailability of green tea polyphenols using nanotechnological approaches, which in turn would aid in enhancing their therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)139-151
Number of pages13
JournalJournal of Functional Foods
Volume34
DOIs
StatePublished - Jul 1 2017
Externally publishedYes

Keywords

  • Bioavailability
  • Green tea
  • Nanoencapsulation
  • Polyphenols
  • Solid lipid nanoparticle
  • Therapeutic efficacy

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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