TY - JOUR
T1 - Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols
AU - Puligundla, Pradeep
AU - Mok, Chulkyoon
AU - Ko, Sanghoon
AU - Liang, Jin
AU - Recharla, Neeraja
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Green tea contains numerous bioactive compounds that may provide multiple health benefits, including antioxidative, anti-inflammatory, anti-carcinogenic, anti-proliferative, anti-hypertensive, antithrombogenic and lipid-lowering effects. Most of the chemopreventive and therapeutic effects of green tea extracts have been attributed to the presence of different polyphenolic bioactives, especially catechins, in their composition. Although these polyphenolic compounds have been shown promising therapeutic effects under in vitro conditions, they met with limited efficacy in clinical settings due to various reasons such as poor oral absorption and bioavailability. Different techniques have been proposed to improve the bioavailability of green tea polyphenols. Among such strategies, nanoparticle-based delivery systems are novel and promising tools. This review is intended to discuss the advances related to improvement of in vitro and in vivo bioavailability of green tea polyphenols using nanotechnological approaches, which in turn would aid in enhancing their therapeutic efficacy.
AB - Green tea contains numerous bioactive compounds that may provide multiple health benefits, including antioxidative, anti-inflammatory, anti-carcinogenic, anti-proliferative, anti-hypertensive, antithrombogenic and lipid-lowering effects. Most of the chemopreventive and therapeutic effects of green tea extracts have been attributed to the presence of different polyphenolic bioactives, especially catechins, in their composition. Although these polyphenolic compounds have been shown promising therapeutic effects under in vitro conditions, they met with limited efficacy in clinical settings due to various reasons such as poor oral absorption and bioavailability. Different techniques have been proposed to improve the bioavailability of green tea polyphenols. Among such strategies, nanoparticle-based delivery systems are novel and promising tools. This review is intended to discuss the advances related to improvement of in vitro and in vivo bioavailability of green tea polyphenols using nanotechnological approaches, which in turn would aid in enhancing their therapeutic efficacy.
KW - Bioavailability
KW - Green tea
KW - Nanoencapsulation
KW - Polyphenols
KW - Solid lipid nanoparticle
KW - Therapeutic efficacy
UR - http://www.scopus.com/inward/record.url?scp=85018783443&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018783443&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2017.04.023
DO - 10.1016/j.jff.2017.04.023
M3 - Review article
AN - SCOPUS:85018783443
SN - 1756-4646
VL - 34
SP - 139
EP - 151
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -