Nasal challenge test in the diagnosis of allergic respiratory diseases in subjects occupationally exposed to a high molecular allergen (flour)

P. Górski, A. Krakowiak, K. Pazdrak, C. Palczynski, U. Ruta, J. Walusiak

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The objective of this study was the evaluation of the usefulness of the nasal challenge test in the diagnosis of allergic respiratory diseases in subjects occupationally exposed to flour. A single-blind, placebo controlled study was conducted in 100 subjects with occupational atopic asthma with rhinitis. The control groups consisted of 20 atopic subjects not sensitized to investigated allergens and 20 healthy subjects. A 'nasal pool' technique was used to evaluate the changes of the cellular response and protein level in nasal washings after topical provocation with allergen or placebo. The concentrations of eosinophil cationic protein and mast cell-derived tryptase in nasal fluid were evaluated in 60 cases. There were significant increases in eosinophil and basophils number, albumin/total protein ratio, eosinophil cationic protein and tryptase levels in occupationally sensitized patients challenged with specific allergens. There were neither severe bronchial reactions or an increase of bronchial hyperreactivity in occupationally sensitized patients after the nasal provocation with flour. The nasal challenge test appears to be a very useful and safe tool for diagnosing occupational allergy.

Original languageEnglish (US)
Pages (from-to)91-97
Number of pages7
JournalOccupational Medicine
Volume48
Issue number2
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Flour
Nose
Allergens
Eosinophil Cationic Protein
Tryptases
Nasal Lavage Fluid
Placebos
Bronchial Hyperreactivity
Occupational Asthma
Basophils
Rhinitis
Eosinophils
Albumins
Healthy Volunteers
Hypersensitivity
Proteins
Control Groups

Keywords

  • Allergic inflammation
  • Mediators
  • Nasal challenge
  • Occupational allergy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Nasal challenge test in the diagnosis of allergic respiratory diseases in subjects occupationally exposed to a high molecular allergen (flour). / Górski, P.; Krakowiak, A.; Pazdrak, K.; Palczynski, C.; Ruta, U.; Walusiak, J.

In: Occupational Medicine, Vol. 48, No. 2, 1998, p. 91-97.

Research output: Contribution to journalArticle

Górski, P. ; Krakowiak, A. ; Pazdrak, K. ; Palczynski, C. ; Ruta, U. ; Walusiak, J. / Nasal challenge test in the diagnosis of allergic respiratory diseases in subjects occupationally exposed to a high molecular allergen (flour). In: Occupational Medicine. 1998 ; Vol. 48, No. 2. pp. 91-97.
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