Nasopharyngeal carcinoma in children-A retrospective review and demonstration of epstein-barr viral genomes in tumor cell cytoplasm: A report of the pediatric oncology group

Edith P. Hawkins, Jeffrey P. Krischer, Billie E. Smith, Hal K. Hawkins, Milton J. Finegold

Research output: Contribution to journalArticle

31 Scopus citations


Twenty-seven nasopharyngeal carcinomas were entered in the Pediatric Oncology Group Rare Tumor Registry from 1973 to 1988 (15 males, 12 females; 10 white, 15 black, two unknown; ages 8 to 17 years). Eight tumors were non-keratinizing carcinomas (World Health Organization 2) and 19 were undifferentiated (World Health Organization 3). The overall 3-year survival rate was 70% (SE 11%). Nine children developed distant metastases and two were salvaged. We found that localized tumor (P = .02) and black race (P = .05) were associated with a better outcome. In situ hybridization using a biotinylated probe demonstrated Epstein-Barr virus DNA in the cytoplasm of the neoplastic epithelial cells in nine of 11 tumors examined, firmly establishing the presence of Epstein-Barr virus within the malignant cells of nasopharyngeal carcinomas of both World Health Organization 2 and World Health Organization 3 histology, rather than in the surrounding lymphocytes.

Original languageEnglish (US)
Pages (from-to)805-810
Number of pages6
JournalHuman Pathology
Issue number8
StatePublished - 1990
Externally publishedYes



  • children
  • histochemical in situ hybridization
  • nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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