Nasopharyngeal carcinoma in children-A retrospective review and demonstration of epstein-barr viral genomes in tumor cell cytoplasm: A report of the pediatric oncology group

Edith P. Hawkins; Jeffrey P. Krischer; Billie E. Smith; Hal K. Hawkins; Milton J. Finegold

doi:10.1016/0046-8177(90)90049-B

Nasopharyngeal carcinoma in children-A retrospective review and demonstration of epstein-barr viral genomes in tumor cell cytoplasm: A report of the pediatric oncology group

Edith P. Hawkins, Jeffrey P. Krischer, Billie E. Smith, Hal K. Hawkins, Milton J. Finegold

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Twenty-seven nasopharyngeal carcinomas were entered in the Pediatric Oncology Group Rare Tumor Registry from 1973 to 1988 (15 males, 12 females; 10 white, 15 black, two unknown; ages 8 to 17 years). Eight tumors were non-keratinizing carcinomas (World Health Organization 2) and 19 were undifferentiated (World Health Organization 3). The overall 3-year survival rate was 70% (SE 11%). Nine children developed distant metastases and two were salvaged. We found that localized tumor (P = .02) and black race (P = .05) were associated with a better outcome. In situ hybridization using a biotinylated probe demonstrated Epstein-Barr virus DNA in the cytoplasm of the neoplastic epithelial cells in nine of 11 tumors examined, firmly establishing the presence of Epstein-Barr virus within the malignant cells of nasopharyngeal carcinomas of both World Health Organization 2 and World Health Organization 3 histology, rather than in the surrounding lymphocytes.

Original language	English (US)
Pages (from-to)	805-810
Number of pages	6
Journal	Human Pathology
Volume	21
Issue number	8
DOIs	https://doi.org/10.1016/0046-8177(90)90049-B
State	Published - Aug 1990
Externally published	Yes

Keywords

EBV-DNA
children
histochemical in situ hybridization
nasopharyngeal carcinoma

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/0046-8177(90)90049-B

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@article{d8333c274a3b4f1e839f7087592e3277,

title = "Nasopharyngeal carcinoma in children-A retrospective review and demonstration of epstein-barr viral genomes in tumor cell cytoplasm: A report of the pediatric oncology group",

abstract = "Twenty-seven nasopharyngeal carcinomas were entered in the Pediatric Oncology Group Rare Tumor Registry from 1973 to 1988 (15 males, 12 females; 10 white, 15 black, two unknown; ages 8 to 17 years). Eight tumors were non-keratinizing carcinomas (World Health Organization 2) and 19 were undifferentiated (World Health Organization 3). The overall 3-year survival rate was 70\% (SE 11\%). Nine children developed distant metastases and two were salvaged. We found that localized tumor (P = .02) and black race (P = .05) were associated with a better outcome. In situ hybridization using a biotinylated probe demonstrated Epstein-Barr virus DNA in the cytoplasm of the neoplastic epithelial cells in nine of 11 tumors examined, firmly establishing the presence of Epstein-Barr virus within the malignant cells of nasopharyngeal carcinomas of both World Health Organization 2 and World Health Organization 3 histology, rather than in the surrounding lymphocytes.",

keywords = "EBV-DNA, children, histochemical in situ hybridization, nasopharyngeal carcinoma",

author = "Hawkins, \{Edith P.\} and Krischer, \{Jeffrey P.\} and Smith, \{Billie E.\} and Hawkins, \{Hal K.\} and Finegold, \{Milton J.\}",

note = "Funding Information: Support4 in part by grants f{\textquoteright}rom the National Cancer lnsti-tute. and National Inrtitures of Health (CA-03161, Cl-89139. CA-:\textasciitilde{}\textasciitilde{}K\%i9).",

year = "1990",

month = aug,

doi = "10.1016/0046-8177(90)90049-B",

language = "English (US)",

volume = "21",

pages = "805--810",

journal = "Human Pathology",

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T1 - Nasopharyngeal carcinoma in children-A retrospective review and demonstration of epstein-barr viral genomes in tumor cell cytoplasm

T2 - A report of the pediatric oncology group

AU - Hawkins, Edith P.

AU - Krischer, Jeffrey P.

AU - Smith, Billie E.

AU - Hawkins, Hal K.

AU - Finegold, Milton J.

N1 - Funding Information: Support4 in part by grants f’rom the National Cancer lnsti-tute. and National Inrtitures of Health (CA-03161, Cl-89139. CA-:~~K%i9).

PY - 1990/8

Y1 - 1990/8

N2 - Twenty-seven nasopharyngeal carcinomas were entered in the Pediatric Oncology Group Rare Tumor Registry from 1973 to 1988 (15 males, 12 females; 10 white, 15 black, two unknown; ages 8 to 17 years). Eight tumors were non-keratinizing carcinomas (World Health Organization 2) and 19 were undifferentiated (World Health Organization 3). The overall 3-year survival rate was 70% (SE 11%). Nine children developed distant metastases and two were salvaged. We found that localized tumor (P = .02) and black race (P = .05) were associated with a better outcome. In situ hybridization using a biotinylated probe demonstrated Epstein-Barr virus DNA in the cytoplasm of the neoplastic epithelial cells in nine of 11 tumors examined, firmly establishing the presence of Epstein-Barr virus within the malignant cells of nasopharyngeal carcinomas of both World Health Organization 2 and World Health Organization 3 histology, rather than in the surrounding lymphocytes.

AB - Twenty-seven nasopharyngeal carcinomas were entered in the Pediatric Oncology Group Rare Tumor Registry from 1973 to 1988 (15 males, 12 females; 10 white, 15 black, two unknown; ages 8 to 17 years). Eight tumors were non-keratinizing carcinomas (World Health Organization 2) and 19 were undifferentiated (World Health Organization 3). The overall 3-year survival rate was 70% (SE 11%). Nine children developed distant metastases and two were salvaged. We found that localized tumor (P = .02) and black race (P = .05) were associated with a better outcome. In situ hybridization using a biotinylated probe demonstrated Epstein-Barr virus DNA in the cytoplasm of the neoplastic epithelial cells in nine of 11 tumors examined, firmly establishing the presence of Epstein-Barr virus within the malignant cells of nasopharyngeal carcinomas of both World Health Organization 2 and World Health Organization 3 histology, rather than in the surrounding lymphocytes.

KW - EBV-DNA

KW - children

KW - histochemical in situ hybridization

KW - nasopharyngeal carcinoma

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Nasopharyngeal carcinoma in children-A retrospective review and demonstration of epstein-barr viral genomes in tumor cell cytoplasm: A report of the pediatric oncology group

Abstract

Keywords

ASJC Scopus subject areas

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