Natural and nosocomial infection in a patient with West Nile encephalitis and extrapyramidal movement disorders

Tom Solomon, Ann F. Fisher, David W C Beasley, Pitchaiah Mandava, Bruno P. Granwehr, Hans Langsjoen, Amelia P. Travassos Da Rosa, Alan D T Barrett, Robert B. Tesh

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Since its first recognition in North America in 1999, West Nile virus (WNV) has spread rapidly across the continent, but in many communities, rapid diagnostic tests for detection of WNV infection are not fully available. We describe a patient with extrapyramidal movement disorders and changes in the basal ganglia noted on magnetic resonance images that are characteristic of other flavivirus encephalitides and may help in the recognition of patients with West Nile encephalitis. Detailed molecular analysis suggested that, although our patient received a blood transfusion infected with WNV, the virus that caused his initial infection and encephalitis was probably acquired naturally from a mosquito.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume36
Issue number11
DOIs
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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