Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters

Colm Atkins, Jinxin Miao, Birte Kalveram, Terry Juelich, Jennifer K. Smith, David Perez, Lihong Zhang, Jonna L.B. Westover, Arnaud J. Van Wettere, Brian B. Gowen, Zhongde Wang, Alexander N. Freiberg

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Marburg virus (MARV; family Filoviridae) causes sporadic outbreaks of Marburg hemorrhagic fever in sub-Saharan Africa with case fatality rates reaching 90%. Wild-type filoviruses, including MARV and the closely related Ebola virus, are unable to suppress the type I interferon response in rodents, and therefore require adaptation of the viruses to cause disease in immunocompetent animals. In the current study, we demonstrate that STAT2 knockout Syrian hamsters are susceptible to infection with different wildtype MARV variants. MARV Musoke causes a robust and systemic infection resulting in lethal disease. Histopathological findings share features similar to those observed in human patients and other animal models of filovirus infection. Reverse-transcription polymerase chain reaction analysis of host transcripts shows a dysregulation of the innate immune response. Our results demonstrate that the STAT2 knockout hamster represents a novel small animal model of severe MARV infection and disease without the requirement for virus adaptation.

Original languageEnglish (US)
Pages (from-to)S438-S447
JournalJournal of Infectious Diseases
Volume218
DOIs
StatePublished - Nov 22 2018

Keywords

  • Filovirus
  • Marburg virus
  • STAT2 KO hamster
  • animal model.

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters'. Together they form a unique fingerprint.

  • Cite this

    Atkins, C., Miao, J., Kalveram, B., Juelich, T., Smith, J. K., Perez, D., Zhang, L., Westover, J. L. B., Van Wettere, A. J., Gowen, B. B., Wang, Z., & Freiberg, A. N. (2018). Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters. Journal of Infectious Diseases, 218, S438-S447. https://doi.org/10.1093/infdis/jiy457