Natural infection of humans, animals, and phlebotomine sand flies with the Alagoas serotype of vesicular stomatitis virus in Colombia

R. B. Tesh, J. Boshell, G. B. Modi, A. Morales, D. G. Young, A. Corredor, C. Ferro de Carrasquilla, C. de Rodriguez, L. L. Walters, M. O. Gaitan

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Five isolations of the Alagoas serotype of vesicular stomatitis virus (Rhabdoviridae: Vesiculovirus) were made from naturally infected phlebotomine sand flies (Lutzomyia spp.) collected in Colombia. These are the first isolations of Alagoas virus from an arthropod. Replication of the virus occurred in laboratory-reared sand flies (Lutzomyia longipalpis) after inoculation. Bite and transovarial transmissions of the virus was also demonstrated in experimentally infected sand flies. Alagoas virus neutralizing antibodies were found in sera of humans and animals living near the insect collection site; antibody rates among human residents of two nearby towns were 63% and 83%, respectively. Results of comparative serologic studies demonstrated that Alagoas virus is closely related antigenically to Indiana, Cocal, and Maraba viruses and that these four agents form a complex within the vesicular stomatitis virus serogroup. The antigenic similarity among these four viruses makes their differentiation difficult; it also raises doubts about the accuracy of current laboratory methods used for identifying isolates in this serogroup. A discussion follows on the significance of human antibodies to these agents and on the role of sand flies in their ecology.

Original languageEnglish (US)
Pages (from-to)653-661
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume36
Issue number3
StatePublished - 1987
Externally publishedYes

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Vesiculovirus
Rhabdoviridae
Psychodidae
Vesicular Stomatitis
Colombia
Infection
Viruses
Arthropods
Antibodies
Bites and Stings
Serogroup
Neutralizing Antibodies
Ecology
Insects

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Tesh, R. B., Boshell, J., Modi, G. B., Morales, A., Young, D. G., Corredor, A., ... Gaitan, M. O. (1987). Natural infection of humans, animals, and phlebotomine sand flies with the Alagoas serotype of vesicular stomatitis virus in Colombia. American Journal of Tropical Medicine and Hygiene, 36(3), 653-661.

Natural infection of humans, animals, and phlebotomine sand flies with the Alagoas serotype of vesicular stomatitis virus in Colombia. / Tesh, R. B.; Boshell, J.; Modi, G. B.; Morales, A.; Young, D. G.; Corredor, A.; Ferro de Carrasquilla, C.; de Rodriguez, C.; Walters, L. L.; Gaitan, M. O.

In: American Journal of Tropical Medicine and Hygiene, Vol. 36, No. 3, 1987, p. 653-661.

Research output: Contribution to journalArticle

Tesh, RB, Boshell, J, Modi, GB, Morales, A, Young, DG, Corredor, A, Ferro de Carrasquilla, C, de Rodriguez, C, Walters, LL & Gaitan, MO 1987, 'Natural infection of humans, animals, and phlebotomine sand flies with the Alagoas serotype of vesicular stomatitis virus in Colombia', American Journal of Tropical Medicine and Hygiene, vol. 36, no. 3, pp. 653-661.
Tesh, R. B. ; Boshell, J. ; Modi, G. B. ; Morales, A. ; Young, D. G. ; Corredor, A. ; Ferro de Carrasquilla, C. ; de Rodriguez, C. ; Walters, L. L. ; Gaitan, M. O. / Natural infection of humans, animals, and phlebotomine sand flies with the Alagoas serotype of vesicular stomatitis virus in Colombia. In: American Journal of Tropical Medicine and Hygiene. 1987 ; Vol. 36, No. 3. pp. 653-661.
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