Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice

Katherine Taylor; Olga Kolokoltsova; Michael Patterson; Allison Poussard; Jennifer Smith; D. Mark Estes; Slobodan Paessler

doi:10.1016/j.vaccine.2012.03.076

Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice

Katherine Taylor, Olga Kolokoltsova, Michael Patterson, Allison Poussard, Jennifer Smith, D. Mark Estes, Slobodan Paessler

Pathology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

TC83 is a human vaccine with investigational new drug status and is used as a prototype Venezuelan equine encephalitis virus for pathogenesis and antiviral research. Differing from other experimental models, the virus causes high titer infection in the brain and 90-100% mortality in the C3H/HeN murine model. To better characterize the susceptibility to disease development in C3H/HeN mice, we have analyzed the gene transcriptomes and cytokine production in the brains of infected mice. Our analysis indicated the potential importance of natural killer cells in the encephalitic disease development. This paper describes for the first time a pathogenic role for natural killer cells in VEEV encephalitis.

Original language	English (US)
Pages (from-to)	4095-4105
Number of pages	11
Journal	Vaccine
Volume	30
Issue number	27
DOIs	https://doi.org/10.1016/j.vaccine.2012.03.076
State	Published - Jun 8 2012

Keywords

Alphavirus
Encephalitis
Immunology
Natural killer cells
VEEV

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2012.03.076

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title = "Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice",

abstract = "TC83 is a human vaccine with investigational new drug status and is used as a prototype Venezuelan equine encephalitis virus for pathogenesis and antiviral research. Differing from other experimental models, the virus causes high titer infection in the brain and 90-100% mortality in the C3H/HeN murine model. To better characterize the susceptibility to disease development in C3H/HeN mice, we have analyzed the gene transcriptomes and cytokine production in the brains of infected mice. Our analysis indicated the potential importance of natural killer cells in the encephalitic disease development. This paper describes for the first time a pathogenic role for natural killer cells in VEEV encephalitis.",

keywords = "Alphavirus, Encephalitis, Immunology, Natural killer cells, VEEV",

author = "Katherine Taylor and Olga Kolokoltsova and Michael Patterson and Allison Poussard and Jennifer Smith and Estes, {D. Mark} and Slobodan Paessler",

note = "Funding Information: This project was funded through Institute for Human Infections and Immunity at UTMB , Sealy Center for Vaccine Development at UTMB , and the Foreign Animal and Zoonotic Disease Center of Excellence by a grant from the Department of Homeland Security, Science and Technology Directorate, Office of University Programs . Michael Patterson was supported in part by the Institute for Translational Sciences UTMB-NIH grant 1UL1RR029876-01 .",

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doi = "10.1016/j.vaccine.2012.03.076",

language = "English (US)",

volume = "30",

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AU - Taylor, Katherine

AU - Kolokoltsova, Olga

AU - Patterson, Michael

AU - Poussard, Allison

AU - Smith, Jennifer

AU - Estes, D. Mark

AU - Paessler, Slobodan

N1 - Funding Information: This project was funded through Institute for Human Infections and Immunity at UTMB , Sealy Center for Vaccine Development at UTMB , and the Foreign Animal and Zoonotic Disease Center of Excellence by a grant from the Department of Homeland Security, Science and Technology Directorate, Office of University Programs . Michael Patterson was supported in part by the Institute for Translational Sciences UTMB-NIH grant 1UL1RR029876-01 .

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N2 - TC83 is a human vaccine with investigational new drug status and is used as a prototype Venezuelan equine encephalitis virus for pathogenesis and antiviral research. Differing from other experimental models, the virus causes high titer infection in the brain and 90-100% mortality in the C3H/HeN murine model. To better characterize the susceptibility to disease development in C3H/HeN mice, we have analyzed the gene transcriptomes and cytokine production in the brains of infected mice. Our analysis indicated the potential importance of natural killer cells in the encephalitic disease development. This paper describes for the first time a pathogenic role for natural killer cells in VEEV encephalitis.

AB - TC83 is a human vaccine with investigational new drug status and is used as a prototype Venezuelan equine encephalitis virus for pathogenesis and antiviral research. Differing from other experimental models, the virus causes high titer infection in the brain and 90-100% mortality in the C3H/HeN murine model. To better characterize the susceptibility to disease development in C3H/HeN mice, we have analyzed the gene transcriptomes and cytokine production in the brains of infected mice. Our analysis indicated the potential importance of natural killer cells in the encephalitic disease development. This paper describes for the first time a pathogenic role for natural killer cells in VEEV encephalitis.

KW - Alphavirus

KW - Encephalitis

KW - Immunology

KW - Natural killer cells

KW - VEEV

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Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice

Abstract

Keywords

ASJC Scopus subject areas

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