Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice

Katherine Taylor, Olga Kolokoltsova, Michael Patterson, Allison Poussard, Jennifer Smith, D. Mark Estes, Slobodan Paessler

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

TC83 is a human vaccine with investigational new drug status and is used as a prototype Venezuelan equine encephalitis virus for pathogenesis and antiviral research. Differing from other experimental models, the virus causes high titer infection in the brain and 90-100% mortality in the C3H/HeN murine model. To better characterize the susceptibility to disease development in C3H/HeN mice, we have analyzed the gene transcriptomes and cytokine production in the brains of infected mice. Our analysis indicated the potential importance of natural killer cells in the encephalitic disease development. This paper describes for the first time a pathogenic role for natural killer cells in VEEV encephalitis.

Original languageEnglish (US)
Pages (from-to)4095-4105
Number of pages11
JournalVaccine
Volume30
Issue number27
DOIs
StatePublished - Jun 8 2012

Keywords

  • Alphavirus
  • Encephalitis
  • Immunology
  • Natural killer cells
  • VEEV

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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