Abstract
Signaling lymphocytic activation molecule (SLAM, CD150) is the universal morbillivirus receptor. Based on the identification of measles virus (MV) hemagglutinin (H) amino acids supporting human SLAM-dependent cell entry, we mutated canine distemper virus (CDV) H and identified residues necessary for efficient canine SLAM-dependent membrane fusion. These residues are located in two nearby clusters in a new CDV H structural model. To completely abolish SLAM-dependent fusion, combinations of mutations were necessary. We rescued a SLAM-blind recombinant CDV with six mutations that did not infect ferret peripheral blood mononuclear cells while retaining full infectivity in epithelial cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5857-5862 |
| Number of pages | 6 |
| Journal | Journal of virology |
| Volume | 79 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 1 2005 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology
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Von Messling, V., Oezguen, N., Zheng, Q., Vongpunsawad, S., Braun, W., & Cattaneo, R. (2005). Nearby clusters of hemagglutinin residues sustain SLAM-dependent canine distemper virus entry in peripheral blood mononuclear cells. Journal of virology, 79(9), 5857-5862. https://doi.org/10.1128/JVI.79.9.5857-5862.2005