Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004

Vivek Naranbhai, Natasha Samsunder, Netanya G. Sandler, Annalys Roque, Quarraisha Abdool Karim, Thumbi Ndung'U, William H. Carr, Marcus Altfeld, Daniel C. Douek, Salim S.Abdool Karim

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Innate immune activation was a strong predictor of HIV acquisition in women at risk for HIV in CAPRISA 004. Identifying the cause(s) of activation could enable targeted prevention interventions. In this study, plasma concentrations of lipopolysaccharide, soluble CD14, and intestinal fatty acid-binding protein did not differ between subjects who did or did not subsequently acquire HIV nor were these levels correlated with plasma cytokines or natural killer cell activation. There was no difference between HIV acquirers and non-acquirers in the chemokine and cytokine responses of peripheral blood mononuclear cells stimulated with TLR2, 4, or 7/8 agonists. Further studies are required.

Original languageEnglish (US)
Pages (from-to)294-298
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume63
Issue number3
DOIs
StatePublished - Jul 1 2013

Keywords

  • HIV
  • I-FABP
  • Immune activation
  • LPS
  • Microbial translocation
  • SCD14
  • TLR2
  • TLR4
  • TLR7/8

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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