Neoadjuvant use of ipilimumab in locally advanced melanoma

Lynn J. Howie, Douglas S. Tyler, April K.S. Salama

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations


    Recent advances in immune modulating therapies show great promise for patients with advanced melanoma, however optimal strategies for achieving long-term disease control in locally advanced melanoma are unclear. We present two cases of neoadjuvant ipilimumab, one case in combination with isolated limb infusion (ILI) followed by surgical resection and one followed by surgery alone. Both patients have had durable responses. These cases highlight the ongoing need for prospective trials in the neoadjuvant setting.

    Original languageEnglish (US)
    Pages (from-to)841-843
    Number of pages3
    JournalJournal of Surgical Oncology
    Issue number8
    StatePublished - Dec 15 2015


    • immunotherapy
    • ipilimumab
    • melanoma
    • neoadjuvant

    ASJC Scopus subject areas

    • Surgery
    • Oncology


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