Neonatal drug withdrawal

Mark L. Hudak; Rosemarie C. Tan; Daniel A.C. Frattarelli; Jeffrey L. Galinkin; Thomas P. Green; Kathleen A. Neville; Ian M. Paul; John N. Van Den Anker; Mary Hegenbarth; Matthew Knight; Robert E. Shaddy; Wayne R. Snodgrass; John J. Alexander; Nancy C. Chescheir; Janet D. Cragan; Michael J. Rieder; Adelaide Robb; Hari C. Sachs; Anne Zajicek; George P. Giacoia; Mark Del Monte; Raymond J. Koteras; Lu Ann Papile; Jill E. Baley; Vinod K. Bhutani; Waldemar A. Carlo; James J. Cummings; Praveen Kumar; Richard A. Polin; Kasper S. Wang; Kristi L. Watterberg; David H. Adamkin; Wanda D. Barfield; George Macones; Ann L. Jefferies; Rosalie O. Mainous; Tonse N.K. Raju; William H. Barth; Jim Couto

doi:10.1542/peds.2011-3212

Neonatal drug withdrawal

Mark L. Hudak, Rosemarie C. Tan, Daniel A.C. Frattarelli, Jeffrey L. Galinkin, Thomas P. Green, Kathleen A. Neville, Ian M. Paul, John N. Van Den Anker, Mary Hegenbarth, Matthew Knight, Robert E. Shaddy, Wayne R. Snodgrass, John J. Alexander, Nancy C. Chescheir, Janet D. Cragan, Michael J. Rieder, Adelaide Robb, Hari C. Sachs, Anne Zajicek, George P. GiacoiaMark Del Monte, Raymond J. Koteras, Lu Ann Papile, Jill E. Baley, Vinod K. Bhutani, Waldemar A. Carlo, James J. Cummings, Praveen Kumar, Richard A. Polin, Kasper S. Wang, Kristi L. Watterberg, David H. Adamkin, Wanda D. Barfield, George Macones, Ann L. Jefferies, Rosalie O. Mainous, Tonse N.K. Raju, William H. Barth, Jim Couto

Pharmacology & Toxicology

Research output: Contribution to journal › Article › peer-review

716 Scopus citations

Abstract

Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug effect. In addition, hospitalized infants who are treated with opioids or benzodiazepines to provide analgesia or sedation may be at risk for manifesting signs of withdrawal. This statement updates information about the clinical presentation of infants exposed to intrauterine drugs and the therapeutic options for treatment of withdrawal and is expanded to include evidence-based approaches to the management of the hospitalized infant who requires weaning from analgesics or sedatives.

Original language	English (US)
Pages (from-to)	e540-e560
Journal	Pediatrics
Volume	129
Issue number	2
DOIs	https://doi.org/10.1542/peds.2011-3212
State	Published - Feb 2012

Keywords

Abstinence syndrome
Benzodiazepine
Cocaine
Drug withdrawal
Fentanyl
Heroin
Methadone
Methamphetamine
Neonate
Opioid
SSRI

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1542/peds.2011-3212

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Hudak, M. L., Tan, R. C., Frattarelli, D. A. C., Galinkin, J. L., Green, T. P., Neville, K. A., Paul, I. M., Van Den Anker, J. N., Hegenbarth, M., Knight, M., Shaddy, R. E., Snodgrass, W. R., Alexander, J. J., Chescheir, N. C., Cragan, J. D., Rieder, M. J., Robb, A., Sachs, H. C., Zajicek, A., ... Couto, J. (2012). Neonatal drug withdrawal. Pediatrics, 129(2), e540-e560. https://doi.org/10.1542/peds.2011-3212

Hudak, ML, Tan, RC, Frattarelli, DAC, Galinkin, JL, Green, TP, Neville, KA, Paul, IM, Van Den Anker, JN, Hegenbarth, M, Knight, M, Shaddy, RE, Snodgrass, WR, Alexander, JJ, Chescheir, NC, Cragan, JD, Rieder, MJ, Robb, A, Sachs, HC, Zajicek, A, Giacoia, GP, Del Monte, M, Koteras, RJ, Papile, LA, Baley, JE, Bhutani, VK, Carlo, WA, Cummings, JJ, Kumar, P, Polin, RA, Wang, KS, Watterberg, KL, Adamkin, DH, Barfield, WD, Macones, G, Jefferies, AL, Mainous, RO, Raju, TNK, Barth, WH & Couto, J 2012, 'Neonatal drug withdrawal', Pediatrics, vol. 129, no. 2, pp. e540-e560. https://doi.org/10.1542/peds.2011-3212

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Neonatal drug withdrawal

Abstract

Keywords

ASJC Scopus subject areas

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