Neonatal drug withdrawal

Mark L. Hudak, Rosemarie C. Tan, Daniel A C Frattarelli, Jeffrey L. Galinkin, Thomas P. Green, Kathleen A. Neville, Ian M. Paul, John N. Van Den Anker, Mary Hegenbarth, Matthew Knight, Robert E. Shaddy, Wayne R. Snodgrass, John J. Alexander, Nancy C. Chescheir, Janet D. Cragan, Michael J. Rieder, Adelaide Robb, Hari C. Sachs, Anne Zajicek, George P. GiacoiaMark Del Monte, Raymond J. Koteras, Lu Ann Papile, Jill E. Baley, Vinod K. Bhutani, Waldemar A. Carlo, James J. Cummings, Praveen Kumar, Richard A. Polin, Kasper S. Wang, Kristi L. Watterberg, David H. Adamkin, Wanda D. Barfield, George Macones, Ann L. Jefferies, Rosalie O. Mainous, Tonse N K Raju, William H. Barth, Jim Couto

Research output: Contribution to journalArticle

396 Citations (Scopus)

Abstract

Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug effect. In addition, hospitalized infants who are treated with opioids or benzodiazepines to provide analgesia or sedation may be at risk for manifesting signs of withdrawal. This statement updates information about the clinical presentation of infants exposed to intrauterine drugs and the therapeutic options for treatment of withdrawal and is expanded to include evidence-based approaches to the management of the hospitalized infant who requires weaning from analgesics or sedatives.

Original languageEnglish (US)
JournalPediatrics
Volume129
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Pharmaceutical Preparations
Weaning
Hypnotics and Sedatives
Benzodiazepines
Analgesia
Opioid Analgesics
Analgesics
Mothers
Pregnancy
Therapeutics
Drugs
Drug Effects
Causes
Toxicity

Keywords

  • Abstinence syndrome
  • Benzodiazepine
  • Cocaine
  • Drug withdrawal
  • Fentanyl
  • Heroin
  • Methadone
  • Methamphetamine
  • Neonate
  • Opioid
  • SSRI

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Arts and Humanities (miscellaneous)

Cite this

Hudak, M. L., Tan, R. C., Frattarelli, D. A. C., Galinkin, J. L., Green, T. P., Neville, K. A., ... Couto, J. (2012). Neonatal drug withdrawal. Pediatrics, 129(2). https://doi.org/10.1542/peds.2011-3212

Neonatal drug withdrawal. / Hudak, Mark L.; Tan, Rosemarie C.; Frattarelli, Daniel A C; Galinkin, Jeffrey L.; Green, Thomas P.; Neville, Kathleen A.; Paul, Ian M.; Van Den Anker, John N.; Hegenbarth, Mary; Knight, Matthew; Shaddy, Robert E.; Snodgrass, Wayne R.; Alexander, John J.; Chescheir, Nancy C.; Cragan, Janet D.; Rieder, Michael J.; Robb, Adelaide; Sachs, Hari C.; Zajicek, Anne; Giacoia, George P.; Del Monte, Mark; Koteras, Raymond J.; Papile, Lu Ann; Baley, Jill E.; Bhutani, Vinod K.; Carlo, Waldemar A.; Cummings, James J.; Kumar, Praveen; Polin, Richard A.; Wang, Kasper S.; Watterberg, Kristi L.; Adamkin, David H.; Barfield, Wanda D.; Macones, George; Jefferies, Ann L.; Mainous, Rosalie O.; Raju, Tonse N K; Barth, William H.; Couto, Jim.

In: Pediatrics, Vol. 129, No. 2, 02.2012.

Research output: Contribution to journalArticle

Hudak, ML, Tan, RC, Frattarelli, DAC, Galinkin, JL, Green, TP, Neville, KA, Paul, IM, Van Den Anker, JN, Hegenbarth, M, Knight, M, Shaddy, RE, Snodgrass, WR, Alexander, JJ, Chescheir, NC, Cragan, JD, Rieder, MJ, Robb, A, Sachs, HC, Zajicek, A, Giacoia, GP, Del Monte, M, Koteras, RJ, Papile, LA, Baley, JE, Bhutani, VK, Carlo, WA, Cummings, JJ, Kumar, P, Polin, RA, Wang, KS, Watterberg, KL, Adamkin, DH, Barfield, WD, Macones, G, Jefferies, AL, Mainous, RO, Raju, TNK, Barth, WH & Couto, J 2012, 'Neonatal drug withdrawal', Pediatrics, vol. 129, no. 2. https://doi.org/10.1542/peds.2011-3212
Hudak ML, Tan RC, Frattarelli DAC, Galinkin JL, Green TP, Neville KA et al. Neonatal drug withdrawal. Pediatrics. 2012 Feb;129(2). https://doi.org/10.1542/peds.2011-3212
Hudak, Mark L. ; Tan, Rosemarie C. ; Frattarelli, Daniel A C ; Galinkin, Jeffrey L. ; Green, Thomas P. ; Neville, Kathleen A. ; Paul, Ian M. ; Van Den Anker, John N. ; Hegenbarth, Mary ; Knight, Matthew ; Shaddy, Robert E. ; Snodgrass, Wayne R. ; Alexander, John J. ; Chescheir, Nancy C. ; Cragan, Janet D. ; Rieder, Michael J. ; Robb, Adelaide ; Sachs, Hari C. ; Zajicek, Anne ; Giacoia, George P. ; Del Monte, Mark ; Koteras, Raymond J. ; Papile, Lu Ann ; Baley, Jill E. ; Bhutani, Vinod K. ; Carlo, Waldemar A. ; Cummings, James J. ; Kumar, Praveen ; Polin, Richard A. ; Wang, Kasper S. ; Watterberg, Kristi L. ; Adamkin, David H. ; Barfield, Wanda D. ; Macones, George ; Jefferies, Ann L. ; Mainous, Rosalie O. ; Raju, Tonse N K ; Barth, William H. ; Couto, Jim. / Neonatal drug withdrawal. In: Pediatrics. 2012 ; Vol. 129, No. 2.
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