TY - JOUR
T1 - Neonatal gastric motility in dogs
T2 - Maturation and response to pentagastrin
AU - Malloy, M. G.
AU - Morriss, F. H.
AU - Denson, S. E.
PY - 1979
Y1 - 1979
N2 - Postnatal changes in the pH of gastric secretions, gastric motility, serum gastrin concentration, and response of the stomach to pentagastrin administration were studied in 15 beagle puppies from birth to 5 wk of age. Motility was monitored manometrically via twin-lumen catheters 3-6 hr postprandially. Mean gastric pH was stable at 5.85 until the 7th postnatal day when pH decreased to 3.45; pH then increased to a mean value of 4.95 through the 18th day. Antral contractions increased from 0.2 contractions per min on the day of birth to a maximum 2.3 contractions per min on the 11th day and then gradually declined. Pentagastrin (8.0 μg/kg sec) had no effect on gastric pH or motility until the 2nd postnatal wk. Pentagastrin inhibited the rate and peak pressure of antral contractions from the 2nd through the 5th wk. Mean serum gastrin concentrations in 6 puppies were greater than values for adult dogs, attaining a preweaning maximum on the 9th day.
AB - Postnatal changes in the pH of gastric secretions, gastric motility, serum gastrin concentration, and response of the stomach to pentagastrin administration were studied in 15 beagle puppies from birth to 5 wk of age. Motility was monitored manometrically via twin-lumen catheters 3-6 hr postprandially. Mean gastric pH was stable at 5.85 until the 7th postnatal day when pH decreased to 3.45; pH then increased to a mean value of 4.95 through the 18th day. Antral contractions increased from 0.2 contractions per min on the day of birth to a maximum 2.3 contractions per min on the 11th day and then gradually declined. Pentagastrin (8.0 μg/kg sec) had no effect on gastric pH or motility until the 2nd postnatal wk. Pentagastrin inhibited the rate and peak pressure of antral contractions from the 2nd through the 5th wk. Mean serum gastrin concentrations in 6 puppies were greater than values for adult dogs, attaining a preweaning maximum on the 9th day.
UR - http://www.scopus.com/inward/record.url?scp=0018357463&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018357463&partnerID=8YFLogxK
U2 - 10.1152/ajpendo.1979.236.5.e562
DO - 10.1152/ajpendo.1979.236.5.e562
M3 - Article
C2 - 35982
AN - SCOPUS:0018357463
SN - 0363-6100
VL - 5
SP - E562-E566
JO - American Journal of Physiology Endocrinology Metabolism and Gastrointestinal Physiology
JF - American Journal of Physiology Endocrinology Metabolism and Gastrointestinal Physiology
IS - 5
ER -