Neonatal lead toxicity and in vitro lipid peroxidation of rat brain

Benjamin B. Gelman, I. Arthur Michaelson

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Neonatal rats were given aqueous lead acetate intragastrically from d 2-20 of life at doses of 0, 25, 75, and 225 mg Pb/kg·d. Blood Pb concentrations on d 21 were (mean ± SE) 27 ± 4 (control), 150 ± 26, 263 ± 63, and 518 ± 97 μg/100 ml, respectively. Growth was significantly depressed only in animals given the highest dose of Pb (225 mg/kg·d). Hematocrits were significantly decreased by d21 at all doses of Pb. Malondialdehyde (MDA) formation in 750 X g (10 min) brain supernatants induced spontaneously by aerobic incubation at 37°C was not altered by Pb on d 7 and 14, but a slight decrease was observed on d 21. The extent of MDA formation induced by enzymatically generated superoxide anion was not altered by Pb toxicity during the first 21 d of life. Addition of Pb to 750 X g (10 min) brain supernatants in vitro significantly decreased MDA formation at Pb concentrations of 10-5 M and higher. These results show that the central nervous system toxicity of Pb in neonatal rats is not associated with accelerated in vitro Iipid peroxidation of brain tissue.

Original languageEnglish (US)
Pages (from-to)671-682
Number of pages12
JournalJournal of Toxicology and Environmental Health
Volume5
Issue number4
DOIs
StatePublished - Jul 1979

ASJC Scopus subject areas

  • Toxicology
  • Pollution

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