Nerve growth factor and neural oncology

S. A. Vinores, J. R. Perez Polo

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    Abstract

    The precise role of the nerve growth factor protein (NGF) during the growth and development of the human nervous system is not determined. Although it appears to influence a number of neural functions, its mechanism of action is poorly understood. A number of researchers have proposed that NGF may be involved in several pathological conditions including cancer. It has been shown that NGF is secreted by certain sarcoma (23), neuroblastoma (113), and glioma (7, 102, 136) cell lines and can bind to neuroblastoma and metastatic melanoma cell lines (42). Neuroblastoma (136, 181) and pheochromocytoma (165) cells in vitro can be induced by NGF to differentiate toward a morphologicaly 'more benign' state and appropriate NGF treatment of rats can reduce the number of chemically induced gliomas and neurinomas (174, 178). NGF can also reduce the growth of intracerebrally inoculated anaplastic glioma cells (172). Anti-NGF treatment of rats (178) and mice (179) can alter the tumor distribution observed following ethylnitrosourea or benzo(a)pyrene treatment (10). In humans, it has been reported that serum levels of NGF are usually elevated in persons 'at risk' for neurofibromatosis (156). The precise nature of the NGF role is not known in these instances. Further understanding of the action of NGF could be of clinical importance.

    Original languageEnglish (US)
    Pages (from-to)81-100
    Number of pages20
    JournalJournal of Neuroscience Research
    Volume9
    Issue number1
    StatePublished - 1983

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    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Vinores, S. A., & Perez Polo, J. R. (1983). Nerve growth factor and neural oncology. Journal of Neuroscience Research, 9(1), 81-100.