Nerve growth factor and neuronal cell death

J. Regino Perez-Polo, Perry J. Foreman, George R. Jackson, Din e. Shan, Giulio Taglialatela, Larry W. Thorpe, Karin Werrbach-Perez

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The regulation of neuronal cell death by the neuronotrophic factor, nerve growth factor (NGF), has been described during neural development and following injury to the nervous system. Also, reduced NGF activity has been reported for the aged NGF-responsive neurons of the sympathetic nervous system and cholinergic regions of the central nervous system (CNS) in aged rodents and man. Although there is some knowledge of the molecular structure of the NGF and its receptor, less is known as to the mechanism of action of NGF. Here, a possible role for NGF in the regulation of oxidant-antioxidant balance is discussed as part of a molecular explanation for the known effects of NGF on neuronal survival during development, after injury, and in the aged CNS.

Original languageEnglish (US)
Pages (from-to)57-91
Number of pages35
JournalMolecular Neurobiology
Volume4
Issue number1-2
DOIs
StatePublished - Mar 1990

Fingerprint

Nerve Growth Factor
Cell Death
Central Nervous System
Nervous System Trauma
Nerve Growth Factor Receptor
Sympathetic Nervous System
Nerve Growth Factors
Molecular Structure
Oxidants
Cholinergic Agents
Rodentia
Antioxidants
Neurons
Wounds and Injuries

Keywords

  • acetyl-l-carnitine
  • aged
  • astrocyte lymphocyte
  • cell death
  • growth factor
  • mitogen
  • neurotrophic factor
  • NGF
  • NGF receptor
  • purification
  • receptor-associated protein
  • retinoic acid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Perez-Polo, J. R., Foreman, P. J., Jackson, G. R., Shan, D. E., Taglialatela, G., Thorpe, L. W., & Werrbach-Perez, K. (1990). Nerve growth factor and neuronal cell death. Molecular Neurobiology, 4(1-2), 57-91. https://doi.org/10.1007/BF02935585

Nerve growth factor and neuronal cell death. / Perez-Polo, J. Regino; Foreman, Perry J.; Jackson, George R.; Shan, Din e.; Taglialatela, Giulio; Thorpe, Larry W.; Werrbach-Perez, Karin.

In: Molecular Neurobiology, Vol. 4, No. 1-2, 03.1990, p. 57-91.

Research output: Contribution to journalArticle

Perez-Polo, JR, Foreman, PJ, Jackson, GR, Shan, DE, Taglialatela, G, Thorpe, LW & Werrbach-Perez, K 1990, 'Nerve growth factor and neuronal cell death', Molecular Neurobiology, vol. 4, no. 1-2, pp. 57-91. https://doi.org/10.1007/BF02935585
Perez-Polo JR, Foreman PJ, Jackson GR, Shan DE, Taglialatela G, Thorpe LW et al. Nerve growth factor and neuronal cell death. Molecular Neurobiology. 1990 Mar;4(1-2):57-91. https://doi.org/10.1007/BF02935585
Perez-Polo, J. Regino ; Foreman, Perry J. ; Jackson, George R. ; Shan, Din e. ; Taglialatela, Giulio ; Thorpe, Larry W. ; Werrbach-Perez, Karin. / Nerve growth factor and neuronal cell death. In: Molecular Neurobiology. 1990 ; Vol. 4, No. 1-2. pp. 57-91.
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