Nerve growth factor and neuronal cell death

J. Regino Perez-Polo, Perry J. Foreman, George R. Jackson, Din e. Shan, Giulio Taglialatela, Larry W. Thorpe, Karin Werrbach-Perez

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The regulation of neuronal cell death by the neuronotrophic factor, nerve growth factor (NGF), has been described during neural development and following injury to the nervous system. Also, reduced NGF activity has been reported for the aged NGF-responsive neurons of the sympathetic nervous system and cholinergic regions of the central nervous system (CNS) in aged rodents and man. Although there is some knowledge of the molecular structure of the NGF and its receptor, less is known as to the mechanism of action of NGF. Here, a possible role for NGF in the regulation of oxidant-antioxidant balance is discussed as part of a molecular explanation for the known effects of NGF on neuronal survival during development, after injury, and in the aged CNS.

Original languageEnglish (US)
Pages (from-to)57-91
Number of pages35
JournalMolecular Neurobiology
Volume4
Issue number1-2
DOIs
StatePublished - Mar 1 1990

Keywords

  • NGF
  • NGF receptor
  • acetyl-l-carnitine
  • aged
  • astrocyte lymphocyte
  • cell death
  • growth factor
  • mitogen
  • neurotrophic factor
  • purification
  • receptor-associated protein
  • retinoic acid

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Perez-Polo, J. R., Foreman, P. J., Jackson, G. R., Shan, D. E., Taglialatela, G., Thorpe, L. W., & Werrbach-Perez, K. (1990). Nerve growth factor and neuronal cell death. Molecular Neurobiology, 4(1-2), 57-91. https://doi.org/10.1007/BF02935585