Nerve growth factor and p75(NGFR) factor receptor mRNA change in rodent CNS following stress activation of the hypothalamo-pituitary-adrenocortical axis

P. J. Foreman, Giulio Taglialatela, L. Angelucci, C. P. Turner, J. R. Perez-Polo

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    The synthesis of nerve growth factor (NGF) by the hippocampus raises the possibility that NGF may play a role in the regulation of the hypothalamic- pituitary-adrenal axis (HPAA). Subchronic cold stress has been shown to activate the HPAA in a mild noninvasive manner, to stimulate serum glucocorticoid levels, and to perturb NGF binding in hippocampus and basal forebrain. One or repeated episodes of cold stress increased NGF mRNA levels in the hippocampus and p75(NGFR) mRNA levels in the basal forebrain. These changes were not due to elevated serum glucocorticoid levels since treatment with exogenous corticosterone had no effect on NGF and p75(NGFR) mRNA levels. Adrenalectomy did not prevent the stress induced increases in NGF and p75(NGFR) mRNA.

    Original languageEnglish (US)
    Pages (from-to)10-18
    Number of pages9
    JournalJournal of Neuroscience Research
    Volume36
    Issue number1
    StatePublished - 1993

    Fingerprint

    Nerve Growth Factor Receptor
    Nerve Growth Factor
    Rodentia
    Messenger RNA
    Hippocampus
    Glucocorticoids
    Adrenalectomy
    Corticosterone
    Serum

    Keywords

    • corticosteroid
    • hypothalamus
    • neurotrophin receptor
    • stress hippocampus

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Nerve growth factor and p75(NGFR) factor receptor mRNA change in rodent CNS following stress activation of the hypothalamo-pituitary-adrenocortical axis. / Foreman, P. J.; Taglialatela, Giulio; Angelucci, L.; Turner, C. P.; Perez-Polo, J. R.

    In: Journal of Neuroscience Research, Vol. 36, No. 1, 1993, p. 10-18.

    Research output: Contribution to journalArticle

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