Nerve growth factor and p75(NGFR) factor receptor mRNA change in rodent CNS following stress activation of the hypothalamo-pituitary-adrenocortical axis

P. J. Foreman, Giulio Taglialatela, L. Angelucci, C. P. Turner, J. R. Perez-Polo

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    Abstract

    The synthesis of nerve growth factor (NGF) by the hippocampus raises the possibility that NGF may play a role in the regulation of the hypothalamic- pituitary-adrenal axis (HPAA). Subchronic cold stress has been shown to activate the HPAA in a mild noninvasive manner, to stimulate serum glucocorticoid levels, and to perturb NGF binding in hippocampus and basal forebrain. One or repeated episodes of cold stress increased NGF mRNA levels in the hippocampus and p75(NGFR) mRNA levels in the basal forebrain. These changes were not due to elevated serum glucocorticoid levels since treatment with exogenous corticosterone had no effect on NGF and p75(NGFR) mRNA levels. Adrenalectomy did not prevent the stress induced increases in NGF and p75(NGFR) mRNA.

    Original languageEnglish (US)
    Pages (from-to)10-18
    Number of pages9
    JournalJournal of Neuroscience Research
    Volume36
    Issue number1
    StatePublished - 1993

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    Keywords

    • corticosteroid
    • hypothalamus
    • neurotrophin receptor
    • stress hippocampus

    ASJC Scopus subject areas

    • Neuroscience(all)

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