Nerve growth factor and p75NGFR factor receptor mRNA change in rodent CNS following stress activation of the hypothalamo‐pituitary‐adrenocortical axis

P. J. Foreman, G. Taglialatela, L. Angelucci, C. P. Turner, J. R. Perez‐Polo

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

The synthesis of nerve growth factor (NGF) by the hippocampus raises the possibility that NGF may play a role in the regulation of the hypothalamic‐pituitary‐adrenal axis (HPAA). Subchronic cold stress has been shown to activate the HPAA in a mild noninvasive manner, to stimulate serum glucocorticoid levels, and to perturb NGF binding in hippocampus and basal forebrain. One or repeated episodes of cold stress increased NGF mRNA levels in the hippocampus and p75NGFR mRNA levels in the basal forebrain. These changes were not due to elevated serum glucocorticoid levels since treatment with exogenous corticosterone had no effect on NGF and p75NGFR mRNA levels. Adrenalectomy did not prevent the stress induced increases in NGF and p75NGFR mRNA. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)10-18
Number of pages9
JournalJournal of Neuroscience Research
Volume36
Issue number1
DOIs
StatePublished - Sep 1 1993

Keywords

  • corticosteroid
  • hypothalamus
  • neurotrophin receptor
  • stress hippocampus

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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