Nerve growth factor binding in aged rat central nervous system: Effect of acetyl-L-carnitine

L. Angelucci, M. T. Ramacci, Giulio Taglialatela, C. Hulsebosch, B. Morgan, K. Werrbach-Perez, R. Perez-Polo

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Abstract

The nerve growth factor protein (NGF) has been demonstrated to affect neuronal development and maintenance of the differentiated state in certain neurons of the peripheral and central nervous system (CNS) of mammals. In the CNS, NGF has sparing effects on cholinergic neurons of the rodent basal forebrain (BF) following lesions where it selectively induces choline acetyltransferase (ChAT). NGF also induces ChAT in the areas to which BF provides afferents. In aged rats, there is a reduction in the NGF-binding capacity of sympathetic ganglia. Here, we wish to report that there is a decrease in the NGF-binding capacity of the hippocampus and basal forebrain of aged (26-month-old) rats as compared to 4-month-old controls but no change in NGF binding in cerebellum. In all instances, equilibrium binding dissociated constants did not differ significantly. Treatment of rats with acetyl-L-carnitine, reported to improve cognitive performance of aged rats, ameliorates these age-related deficits.

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalJournal of Neuroscience Research
Volume20
Issue number4
StatePublished - 1988

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Acetylcarnitine
Nerve Growth Factor
Central Nervous System
Protein Binding
Choline O-Acetyltransferase
Sympathetic Ganglia
Proteins
Cholinergic Neurons
Peripheral Nervous System
Cerebellum
Mammals
Rodentia
Hippocampus
Maintenance
Neurons
Basal Forebrain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Angelucci, L., Ramacci, M. T., Taglialatela, G., Hulsebosch, C., Morgan, B., Werrbach-Perez, K., & Perez-Polo, R. (1988). Nerve growth factor binding in aged rat central nervous system: Effect of acetyl-L-carnitine. Journal of Neuroscience Research, 20(4), 491-496.

Nerve growth factor binding in aged rat central nervous system : Effect of acetyl-L-carnitine. / Angelucci, L.; Ramacci, M. T.; Taglialatela, Giulio; Hulsebosch, C.; Morgan, B.; Werrbach-Perez, K.; Perez-Polo, R.

In: Journal of Neuroscience Research, Vol. 20, No. 4, 1988, p. 491-496.

Research output: Contribution to journalArticle

Angelucci, L, Ramacci, MT, Taglialatela, G, Hulsebosch, C, Morgan, B, Werrbach-Perez, K & Perez-Polo, R 1988, 'Nerve growth factor binding in aged rat central nervous system: Effect of acetyl-L-carnitine', Journal of Neuroscience Research, vol. 20, no. 4, pp. 491-496.
Angelucci L, Ramacci MT, Taglialatela G, Hulsebosch C, Morgan B, Werrbach-Perez K et al. Nerve growth factor binding in aged rat central nervous system: Effect of acetyl-L-carnitine. Journal of Neuroscience Research. 1988;20(4):491-496.
Angelucci, L. ; Ramacci, M. T. ; Taglialatela, Giulio ; Hulsebosch, C. ; Morgan, B. ; Werrbach-Perez, K. ; Perez-Polo, R. / Nerve growth factor binding in aged rat central nervous system : Effect of acetyl-L-carnitine. In: Journal of Neuroscience Research. 1988 ; Vol. 20, No. 4. pp. 491-496.
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