Nerve growth factor inhibits Na⁺/H⁺ exchange and HCO₃^- absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb

Keyphrases

• Mammalian Target of Rapamycin (mTOR) 100%
• Nerve Growth Factor 100%
• Phosphoinositide 3-kinase (PI3K) 100%
• Thick Ascending Limb 100%
• H+ Exchange 100%
• HCO3 100%
• Na + 100%
• Extracellular Signal-regulated Kinase Pathway 100%
• Rapamycin 50%
• NHE1 50%
• Downstream Effectors 30%
• Phosphatidylinositol 3-kinase Inhibitor 30%
• P70S6K 30%
• Fold Increase 20%
• Extracellular Signal-regulated Kinase 20%
• Medullary Thick Ascending Limb 20%
• Wortmannin 20%
• Specific Inhibitor 10%
• Signaling Pathway 10%
• Cell Growth 10%
• Basolateral Membrane 10%
• Tumorigenesis 10%
• Kinase Activation 10%
• NHE3 10%
• LY294002 10%
• Ion Exchanger 10%
• Cytoskeleton Remodeling 10%
• Kinase Inhibitor 10%
• Akt Phosphorylation 10%
• Transmembrane Domain 10%
• U0126 10%
• Kinase Target 10%
• Extracellular Signal-regulated Kinase Signaling Pathway 10%
• Parallel Activation 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Mammalian Target of Rapamycin 100%
• Nerve Growth Factor 100%
• Mitogen Activated Protein Kinase 100%
• Phosphatidylinositol 3 Kinase 100%
• Sodium Ion 100%
• Rapamycin 50%
• Phosphatidylinositol 3 Kinase Inhibitor 30%
• S6 Kinase 30%
• Wortmannin 20%
• Carcinogenesis 10%
• Actin 10%
• Cyclic AMP Dependent Protein Kinase 10%
• Phosphotransferase Inhibitor 10%
• 2 Morpholino 8 Phenylchromone 10%
• 1,4 Diamino 1,4 Bis(2 Aminophenylthio) 2,3 Dicyanobutadiene 10%