Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response

Giulio Taglialatela, L. Angelucci, S. Scaccianoce, P. J. Foreman, J. R. Perez-Polo

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

In the present study, we have investigated the functional relationship between the nerve growth factor protein (NGF) and the hypothalamus-pituitary-adrenocortical axis (HPAA) We have found that while iv injected NGF is able to stimulate the HPAA activity in rats, NGF is not able to stimulate the axis after a block of the hypothalamus produced by chlorpromazine-morphine-Nembutal treatment. Also, the stress activation of the HPAA is significantly reduced by pretreatment of the rats with anti-NGF immunoglobulin G. These results suggest that the stimulatory action of NGF on HPAA activity requires the release of ACTH secretagogues from the hypothalamus and that NGF may modulate the HPAA response to stress stimuli.

Original languageEnglish (US)
Pages (from-to)2212-2218
Number of pages7
JournalEndocrinology
Volume129
Issue number4
StatePublished - Oct 1991
Externally publishedYes

Fingerprint

Nerve Growth Factor
Hypothalamus
Proteins
Chlorpromazine
Pentobarbital
Adrenocorticotropic Hormone
Morphine
Immunoglobulin G

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Taglialatela, G., Angelucci, L., Scaccianoce, S., Foreman, P. J., & Perez-Polo, J. R. (1991). Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response. Endocrinology, 129(4), 2212-2218.

Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response. / Taglialatela, Giulio; Angelucci, L.; Scaccianoce, S.; Foreman, P. J.; Perez-Polo, J. R.

In: Endocrinology, Vol. 129, No. 4, 10.1991, p. 2212-2218.

Research output: Contribution to journalArticle

Taglialatela, G, Angelucci, L, Scaccianoce, S, Foreman, PJ & Perez-Polo, JR 1991, 'Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response', Endocrinology, vol. 129, no. 4, pp. 2212-2218.
Taglialatela, Giulio ; Angelucci, L. ; Scaccianoce, S. ; Foreman, P. J. ; Perez-Polo, J. R. / Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response. In: Endocrinology. 1991 ; Vol. 129, No. 4. pp. 2212-2218.
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