Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response

G. Taglialatela, L. Angelucci, S. Scaccianoce, P. J. Foreman, J. R. Perez-Polo

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Abstract

In the present study, we have investigated the functional relationship between the nerve growth factor protein (NGF) and the hypothalamus-pituitary-adrenocortical axis (HPAA) We have found that while iv injected NGF is able to stimulate the HPAA activity in rats, NGF is not able to stimulate the axis after a block of the hypothalamus produced by chlor-promazine-morphine-Nembutal treatment. Also, the stress ac-tivation of the HPAA is significantly reduced by pretreatment of the rats with anti-NGF immunoglobulin G. These results suggest that the stimulatory action of NGF on HPAA activity requires the release of ACTH secretagogues from the hypothalamus and that NGF may modulate the HPAA response to stress stimuli.

Original languageEnglish (US)
Pages (from-to)2212-2218
Number of pages7
JournalEndocrinology
Volume129
Issue number4
DOIs
StatePublished - Oct 1991

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ASJC Scopus subject areas

  • Endocrinology

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