Nerve repair by means of tubulization: Past, present, future

P. Konofaos, J. P. Ver Halen

Research output: Contribution to journalArticlepeer-review

170 Scopus citations


Peripheral nerve injury may result in injury without gaps or injury with gaps between nerve stumps. In the presence of a nerve defect, the placement of an autologous nerve graft is the current gold standard for nerve restoration. The clinical employment of tubes as an alternative to autogenous nerve grafts is mainly justified by the limited availability of donor tissue for nerve autografts and their related morbidity. The purpose of this review is to present an overview of the literature on the applications of nerve conduits in peripheral nerve repair. Moreover, the different steps that are involved in the design of an ideal nerve conduit for peripheral nerve repair, including the choice of biomaterial, fabrication technique, and the various potential modifications to the common hollow nerve tube, are also discussed.

Original languageEnglish (US)
Pages (from-to)149-163
Number of pages15
JournalJournal of Reconstructive Microsurgery
Issue number3
StatePublished - 2013
Externally publishedYes


  • nerve gap
  • nerve guides
  • nerve repair
  • neurotrophic factors

ASJC Scopus subject areas

  • Surgery


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