Neural contribution to interdigestive lower esophageal sphincter pressure phenomena in the conscious opossum

E. L. Blank, R. H. Holloway, W. J. Dodds, R. D. Layman, S. K. Sarna, W. J. Hogan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The genesis of lower esophageal sphincter (LES) pressure in anesthetized opossums is a myogenic phenomenon without excitatory neural input. The mechanism responsible for generating phasic LES pressure phenomena in unanesthetized opossums, however, is not established. In this study, we evaluated the effects of potential pharmacological antagonists on LES pressure phenomena in unanesthetized opossums. We also compared LES responses to pharmacological excitatory agonists in anesthetized and unanesthetized animals. In awake animals the LES exhibited substantial tone as well as characteristic phasic activity. The tonic, or basal, LES pressure did not change during cycling of the migratory motor complex (MMC). However, atropine, 4-diphenylacetoxy-N-methylpiperidine methiodide, and hexamethonium abolished the phasic, MMC-related LES contractions while having no effect on basal pressure. Pirenzepine, prazosin, propranolol, pyrilamine, naloxone, and haloperidol did not affect either phasic or tonic LES pressure phenomena. Anesthesia substantially reduced the excitatory LES response to motilin but not to bethanecol, cholecystokinin-octapeptide, pentagastrin, or phenylephrine. The results suggest that phasic LES contractions related to the MMC cycle are mediated by postganglionic cholinergic nerves with nicotinic ganglionic transmission. Basal LES tone, however, is maintained by a myogenic phenomenon. Anesthesia reduces excitatory LES responses induced by motilin, which acts via excitatory nerves, but has no effect on excitatory responses induced by agents that act mainly or exclusively on LES smooth muscle.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalJournal of Gastrointestinal Motility
Volume2
Issue number1
StatePublished - Jan 1 1990

Keywords

  • Lower esophageal sphincter
  • cholinergic antagonists
  • cholinergic nerves
  • esophageae manometry
  • migrating myoelectric complex

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Neural contribution to interdigestive lower esophageal sphincter pressure phenomena in the conscious opossum'. Together they form a unique fingerprint.

  • Cite this

    Blank, E. L., Holloway, R. H., Dodds, W. J., Layman, R. D., Sarna, S. K., & Hogan, W. J. (1990). Neural contribution to interdigestive lower esophageal sphincter pressure phenomena in the conscious opossum. Journal of Gastrointestinal Motility, 2(1), 23-30.