Neural gastrointestinal electrical stimulation enhances colonic motility in a chronic canine model of delayed colonic transit

C. P. Sanmiguel, S. Casillas, A. Senagore, M. P. Mintchev, E. E. Soffer

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Neural gastrointestinal electrical stimulation (NGES) induces sequential contractions and enhances emptying in acute canine gastric and colonic models. This study was set to determine (i) the effect of NGES in a chronic canine model of delayed colonic transit and (ii) possible mechanism of action. Four pairs of electrodes were implanted in the distal colon of nine mongrel dogs. Delayed colonic transit was induced by diphenoxylate/atropine and alosetron. Transit was fluoroscopically determined by the rate of evacuation of radiopaque markers, and was tested twice in each dog, in random order, on and off stimulation. Two stimulation sequences, separated by 1 min, were delivered twice a day via exteriorized electrodes. Colonic manometry during stimulation was performed before and after intravenous (i.v.) injection of 1 mg of atropine. Complete evacuation of all markers was significantly shortened by NGES, from 4 days to 2 days, interquartile range 3-4 days vs 2-3 days, respectively, P = 0.016. NGES induced strong sequential contractions that were significantly diminished by atropine: 190.0 ± 14.0 mmHg vs 48.7 ± 19.4 mmHg, respectively (P <0.001). NGES induces strong sequential colonic contractions and significantly accelerates movement of content in a canine model of delayed colonic transit. The effect is atropine sensitive.

Original languageEnglish (US)
Pages (from-to)647-653
Number of pages7
JournalNeurogastroenterology and Motility
Volume18
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Electric Stimulation
Canidae
Atropine
Diphenoxylate
Dogs
Implanted Electrodes
Manometry
Intravenous Injections
Stomach
Electrodes
Colon

Keywords

  • Chronic dogs
  • Colon
  • Constipation
  • Delayed colonic transit
  • Electrical stimulation

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

Cite this

Neural gastrointestinal electrical stimulation enhances colonic motility in a chronic canine model of delayed colonic transit. / Sanmiguel, C. P.; Casillas, S.; Senagore, A.; Mintchev, M. P.; Soffer, E. E.

In: Neurogastroenterology and Motility, Vol. 18, No. 8, 08.2006, p. 647-653.

Research output: Contribution to journalArticle

Sanmiguel, C. P. ; Casillas, S. ; Senagore, A. ; Mintchev, M. P. ; Soffer, E. E. / Neural gastrointestinal electrical stimulation enhances colonic motility in a chronic canine model of delayed colonic transit. In: Neurogastroenterology and Motility. 2006 ; Vol. 18, No. 8. pp. 647-653.
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