Neural gastrointestinal electrical stimulation enhances colonic motility in a chronic canine model of delayed colonic transit

C. P. Sanmiguel, S. Casillas, A. Senagore, M. P. Mintchev, E. E. Soffer

    Research output: Contribution to journalArticle

    31 Scopus citations

    Abstract

    Neural gastrointestinal electrical stimulation (NGES) induces sequential contractions and enhances emptying in acute canine gastric and colonic models. This study was set to determine (i) the effect of NGES in a chronic canine model of delayed colonic transit and (ii) possible mechanism of action. Four pairs of electrodes were implanted in the distal colon of nine mongrel dogs. Delayed colonic transit was induced by diphenoxylate/atropine and alosetron. Transit was fluoroscopically determined by the rate of evacuation of radiopaque markers, and was tested twice in each dog, in random order, on and off stimulation. Two stimulation sequences, separated by 1 min, were delivered twice a day via exteriorized electrodes. Colonic manometry during stimulation was performed before and after intravenous (i.v.) injection of 1 mg of atropine. Complete evacuation of all markers was significantly shortened by NGES, from 4 days to 2 days, interquartile range 3-4 days vs 2-3 days, respectively, P = 0.016. NGES induced strong sequential contractions that were significantly diminished by atropine: 190.0 ± 14.0 mmHg vs 48.7 ± 19.4 mmHg, respectively (P < 0.001). NGES induces strong sequential colonic contractions and significantly accelerates movement of content in a canine model of delayed colonic transit. The effect is atropine sensitive.

    Original languageEnglish (US)
    Pages (from-to)647-653
    Number of pages7
    JournalNeurogastroenterology and Motility
    Volume18
    Issue number8
    DOIs
    StatePublished - Aug 1 2006

    Keywords

    • Chronic dogs
    • Colon
    • Constipation
    • Delayed colonic transit
    • Electrical stimulation

    ASJC Scopus subject areas

    • Physiology
    • Endocrine and Autonomic Systems
    • Gastroenterology

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