Neural stem cell transplantation in the enteric nervous system

Roadmaps and roadblocks

K. H. Schäfer, Maria Micci, P. J. Pasricha

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The enteric nervous system (ENS) is vulnerable to a variety of genetic, metabolic or environmental threats, resulting in clinical disorders characterized by loss or malfunction of neuronal elements. These disorders have been difficult to treat and there is much enthusiasm for novel therapies such as neural stem cell (NSC) transplantation to restore ENS function in diseased segments of the gut. Recent research has indicated the potential for a variety of innovative approaches to this effect using NSC obtained from the central nervous system (CNS) as well as gut derived enteric neuronal progenitors. The main goal of this review is to summarize the current status of NSC research as it applies to the ENS, delineate a roadmap for effective therapeutic strategies using NSC transplantation and point out the numerous challenges that lie ahead.

Original languageEnglish (US)
Pages (from-to)103-112
Number of pages10
JournalNeurogastroenterology and Motility
Volume21
Issue number2
DOIs
StatePublished - Feb 2009

Fingerprint

Enteric Nervous System
Neural Stem Cells
Stem Cell Transplantation
Stem Cell Research
Central Nervous System
Therapeutics
Research

Keywords

  • Enteric nervous system
  • Motility disorders
  • Neural stem cells
  • Transplantation

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

Neural stem cell transplantation in the enteric nervous system : Roadmaps and roadblocks. / Schäfer, K. H.; Micci, Maria; Pasricha, P. J.

In: Neurogastroenterology and Motility, Vol. 21, No. 2, 02.2009, p. 103-112.

Research output: Contribution to journalArticle

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