Neuro-ophthalmologic manifestations of cholangiocarcinoma: A case series

G. Rico, S. V. Smith, Yusra Siddiqui, A. Whyte, D. Gombos, A. G. Lee

Research output: Contribution to journalArticle


PurposeTo describe the neuro-ophthalmologic findings of cholangiocarcinoma.MethodsWe report a retrospective chart review of cholangiocarcinoma patients presenting at two tertiary care centers in the Texas Medical Center.ResultsFive patients with neuro-ophthalmologic symptoms related to cholangiocarcinoma were identified. One patient presented with diplopia due to metastasis to the left medial rectus muscle, two patients had metastasis to the occipital lobe resulting in homonymous hemianopsia, one patient had involvement of the clivus resulting in sixth nerve palsy, and one presented with a hypercoagulable state-related stroke causing a homonymous hemianopsia and visual hallucinations.ConclusionsNeuro-ophthalmic manifestations of cholangiocarcinoma depend upon both mechanism and localization. We report five cases of cholangiocarcinoma with neuro-ophthalmologic findings. To our knowledge, this is the largest such series reported in the English language ophthalmic literature.

Original languageEnglish (US)
Pages (from-to)1245-1248
Number of pages4
JournalEye (Basingstoke)
Issue number8
StatePublished - Aug 1 2017


ASJC Scopus subject areas

  • Ophthalmology
  • Arts and Humanities(all)

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