TY - JOUR
T1 - Neurobehavioral effects of neonatal hypermagnesemia
AU - Rasch, Deborah K.
AU - Huber, Patricia A.
AU - Richardson, C. Joan
AU - L'Hommedieu, Charles S.
AU - Nelson, Thomas E.
AU - Reddi, Renuka
PY - 1982/2
Y1 - 1982/2
N2 - To investigate the effects on the newborn infant of maternal magnesium therapy for treatment of pre-eclampsia, we studied 36 hypermagnesemic infants born to pre-eclamptic mothers treated with MgSO4, 18 neonates born to untreated pre-eclamptic mothers, and 25 infants born to normal mothers. Impairment of neuromuscular transmission, as well as neurobehavioral differences when compared to controls, were found in hypermagnesemic infants. Awareness of the changes produced in the neonate by magnesium is important for accurate clinical assessment of the infant's condition, as well as for anticipating the postnatal interaction of magnesium with other drugs administered during labor and delivery.
AB - To investigate the effects on the newborn infant of maternal magnesium therapy for treatment of pre-eclampsia, we studied 36 hypermagnesemic infants born to pre-eclamptic mothers treated with MgSO4, 18 neonates born to untreated pre-eclamptic mothers, and 25 infants born to normal mothers. Impairment of neuromuscular transmission, as well as neurobehavioral differences when compared to controls, were found in hypermagnesemic infants. Awareness of the changes produced in the neonate by magnesium is important for accurate clinical assessment of the infant's condition, as well as for anticipating the postnatal interaction of magnesium with other drugs administered during labor and delivery.
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U2 - 10.1016/S0022-3476(82)80654-9
DO - 10.1016/S0022-3476(82)80654-9
M3 - Article
C2 - 7199083
AN - SCOPUS:0020085837
SN - 0022-3476
VL - 100
SP - 272
EP - 276
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 2
ER -