Neurobiología del estrés agudo y crónico: Su efecto en el eje hipotálamo-hipófisis-adrenal y la memoria

Translated title of the contribution: Neurobiology of acute and chronic stress: Their effect on the hypothalamo-pituitary-adrenal axis and memory

Jorge Mario Rodriǵuez-Fernández, Mary Garciá-Acero, Pamela Franco

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

The presently available data about stress and its effects is too broad. That's why this paper will focus on the effect of stress hormones in some brain areas, like limbic structures and the hypothalamo-pituitary-adrenal axis. In this way we will discuss how repetitive stress can change those areas, mainly by the effect on its two types of nuclear receptors, changing the basal activity of the amygdala, hippocampus and the medial prefrontal cortex, resulting in an increased hypothalamo-pituitary-adrenal axis function and impairing cognitive functions like memory. However, the exact mechanism by which these effects are produced is poorly understood. That is why one of the challenges for future research is to link the cellular changes with its behavioral effects in order to understand how it works in a living organism.

Translated title of the contributionNeurobiology of acute and chronic stress: Their effect on the hypothalamo-pituitary-adrenal axis and memory
Original languageSpanish
Pages (from-to)78-90
Number of pages13
JournalRevista Ecuatoriana de Neurologia
Volume21
Issue number1-3
StatePublished - 2012
Externally publishedYes

Keywords

  • Chronic stress
  • Glucocorticoids
  • Hypothalamo-pituitary-adrenal axis
  • Long-term synaptic potentiation
  • Memory

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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