Neurobiology of cocaine abuse

William L. Woolverton, Kenneth M. Johnson

Research output: Contribution to journalArticle

330 Citations (Scopus)

Abstract

The recent escalation of cocaine abuse has increased awareness of the need to understand the behavioral effects of cocaine and the determinants of those effects. Cocaine alters both conditioned and unconditioned behavior, and has prominent reinforcing and subjective effects that are particularly relevant to its abuse. An increase in CNS dopamine neurotransmission, resulting from a competitive blockade of high-affinity dopamine uptake mediated by both D1 and D2 dopamine receptors, is a primary determinant of the behavioral effects of cocaine. Either tolerance or sensitization may develop with repeated administration of cocaine. Dependence also develops, although the behavioral changes associated with cocaine withdrawal are subtle. Although numerous CNS changes have been associated with repeated administration of cocaine, the neuropharmacological mechanisms that underlie the behavioral changes that occur with repeated administration remain to be firmly established. Bill Woolverton and Ken Johnson stress that continued collaboration between behavioral pharmacologists and neuroscientists is critical for a complete understanding of the effects of cocaine.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalTrends in Pharmacological Sciences
Volume13
Issue numberC
DOIs
StatePublished - 1992

Fingerprint

Cocaine-Related Disorders
Neurobiology
Cocaine
Dopamine
Dopamine D1 Receptors
Dopamine D2 Receptors
Synaptic Transmission

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Neurobiology of cocaine abuse. / Woolverton, William L.; Johnson, Kenneth M.

In: Trends in Pharmacological Sciences, Vol. 13, No. C, 1992, p. 193-200.

Research output: Contribution to journalArticle

Woolverton, William L. ; Johnson, Kenneth M. / Neurobiology of cocaine abuse. In: Trends in Pharmacological Sciences. 1992 ; Vol. 13, No. C. pp. 193-200.
@article{3b8ee0ff22294770a27b64357d202029,
title = "Neurobiology of cocaine abuse",
abstract = "The recent escalation of cocaine abuse has increased awareness of the need to understand the behavioral effects of cocaine and the determinants of those effects. Cocaine alters both conditioned and unconditioned behavior, and has prominent reinforcing and subjective effects that are particularly relevant to its abuse. An increase in CNS dopamine neurotransmission, resulting from a competitive blockade of high-affinity dopamine uptake mediated by both D1 and D2 dopamine receptors, is a primary determinant of the behavioral effects of cocaine. Either tolerance or sensitization may develop with repeated administration of cocaine. Dependence also develops, although the behavioral changes associated with cocaine withdrawal are subtle. Although numerous CNS changes have been associated with repeated administration of cocaine, the neuropharmacological mechanisms that underlie the behavioral changes that occur with repeated administration remain to be firmly established. Bill Woolverton and Ken Johnson stress that continued collaboration between behavioral pharmacologists and neuroscientists is critical for a complete understanding of the effects of cocaine.",
author = "Woolverton, {William L.} and Johnson, {Kenneth M.}",
year = "1992",
doi = "10.1016/0165-6147(92)90063-C",
language = "English (US)",
volume = "13",
pages = "193--200",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "C",

}

TY - JOUR

T1 - Neurobiology of cocaine abuse

AU - Woolverton, William L.

AU - Johnson, Kenneth M.

PY - 1992

Y1 - 1992

N2 - The recent escalation of cocaine abuse has increased awareness of the need to understand the behavioral effects of cocaine and the determinants of those effects. Cocaine alters both conditioned and unconditioned behavior, and has prominent reinforcing and subjective effects that are particularly relevant to its abuse. An increase in CNS dopamine neurotransmission, resulting from a competitive blockade of high-affinity dopamine uptake mediated by both D1 and D2 dopamine receptors, is a primary determinant of the behavioral effects of cocaine. Either tolerance or sensitization may develop with repeated administration of cocaine. Dependence also develops, although the behavioral changes associated with cocaine withdrawal are subtle. Although numerous CNS changes have been associated with repeated administration of cocaine, the neuropharmacological mechanisms that underlie the behavioral changes that occur with repeated administration remain to be firmly established. Bill Woolverton and Ken Johnson stress that continued collaboration between behavioral pharmacologists and neuroscientists is critical for a complete understanding of the effects of cocaine.

AB - The recent escalation of cocaine abuse has increased awareness of the need to understand the behavioral effects of cocaine and the determinants of those effects. Cocaine alters both conditioned and unconditioned behavior, and has prominent reinforcing and subjective effects that are particularly relevant to its abuse. An increase in CNS dopamine neurotransmission, resulting from a competitive blockade of high-affinity dopamine uptake mediated by both D1 and D2 dopamine receptors, is a primary determinant of the behavioral effects of cocaine. Either tolerance or sensitization may develop with repeated administration of cocaine. Dependence also develops, although the behavioral changes associated with cocaine withdrawal are subtle. Although numerous CNS changes have been associated with repeated administration of cocaine, the neuropharmacological mechanisms that underlie the behavioral changes that occur with repeated administration remain to be firmly established. Bill Woolverton and Ken Johnson stress that continued collaboration between behavioral pharmacologists and neuroscientists is critical for a complete understanding of the effects of cocaine.

UR - http://www.scopus.com/inward/record.url?scp=0026603049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026603049&partnerID=8YFLogxK

U2 - 10.1016/0165-6147(92)90063-C

DO - 10.1016/0165-6147(92)90063-C

M3 - Article

VL - 13

SP - 193

EP - 200

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - C

ER -