Neurocognitive impact of substance use in HIV infection

Desiree A. Byrd, Robert P. Fellows, Susan Morgello, Donald Franklin, Robert K. Heaton, Reena Deutsch, J. Hampton Atkinson, David B. Clifford, Ann C. Collier, Christina M. Marra, Benjamin Gelman, J. Allen McCutchan, Nichole A. Duarte, David M. Simpson, Justin McArthur, Igor Grant

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Background: To determine how serious a confound substance use (SU) might be in studies on HIV-associated neurocognitive disorder (HAND), we examined the relationship of SU history to neurocognitive impairment (NCI) in participants enrolled in the Central Nervous System HIV Antiretroviral Therapy Effects Research study. Methods: After excluding cases with behavioral evidence of acute intoxication and histories of factors that independently could account for NCI (eg, stroke), baseline demographic, medical, SU, and neurocognitive data were analyzed from 399 participants. Potential SU risk for NCI was determined by the following criteria: lifetime SU Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis, self-report of marked lifetime SU, or positive urine toxicology. Participants were divided into 3 groups as follows: no SU (n = 134), nonsyndromic SU (n = 131), syndromic SU (n = 134) and matched on literacy level, nadir CD4, and depressive symptoms. RESULTS:: Although approximately 50% of the participants were diagnosed with HAND, a multivariate analysis of covariance of neurocogntive summary scores, covarying for urine toxicology, revealed no significant effect of SU status. Correlational analyses indicated weak associations between lifetime heroin dosage and poor recall and working memory and between cannabis and cocaine use and better verbal fluency. Conclusions: These data indicate that HIV neurocognitive effects are seen at about the same frequency in those with and without historic substance abuse in cases that are equated on other factors that might contribute to NCI. Therefore, studies on neuroAIDS and its treatment need not exclude such cases. However, the effects of acute SU and current SU disorders on HAND require further study.

Original languageEnglish (US)
Pages (from-to)154-162
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes
Volume58
Issue number2
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Fingerprint

HIV Infections
HIV
Toxicology
Substance-Related Disorders
Urine
Heroin
Cannabis
Cocaine
Short-Term Memory
Diagnostic and Statistical Manual of Mental Disorders
Self Report
Multivariate Analysis
Central Nervous System
History
Stroke
Demography
Depression
Research
Neurocognitive Disorders
Therapeutics

Keywords

  • cognition
  • HIV-associated neurocognitive disorder
  • substance use

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Byrd, D. A., Fellows, R. P., Morgello, S., Franklin, D., Heaton, R. K., Deutsch, R., ... Grant, I. (2011). Neurocognitive impact of substance use in HIV infection. Journal of Acquired Immune Deficiency Syndromes, 58(2), 154-162. https://doi.org/10.1097/QAI.0b013e318229ba41

Neurocognitive impact of substance use in HIV infection. / Byrd, Desiree A.; Fellows, Robert P.; Morgello, Susan; Franklin, Donald; Heaton, Robert K.; Deutsch, Reena; Atkinson, J. Hampton; Clifford, David B.; Collier, Ann C.; Marra, Christina M.; Gelman, Benjamin; McCutchan, J. Allen; Duarte, Nichole A.; Simpson, David M.; McArthur, Justin; Grant, Igor.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 58, No. 2, 01.10.2011, p. 154-162.

Research output: Contribution to journalArticle

Byrd, DA, Fellows, RP, Morgello, S, Franklin, D, Heaton, RK, Deutsch, R, Atkinson, JH, Clifford, DB, Collier, AC, Marra, CM, Gelman, B, McCutchan, JA, Duarte, NA, Simpson, DM, McArthur, J & Grant, I 2011, 'Neurocognitive impact of substance use in HIV infection', Journal of Acquired Immune Deficiency Syndromes, vol. 58, no. 2, pp. 154-162. https://doi.org/10.1097/QAI.0b013e318229ba41
Byrd DA, Fellows RP, Morgello S, Franklin D, Heaton RK, Deutsch R et al. Neurocognitive impact of substance use in HIV infection. Journal of Acquired Immune Deficiency Syndromes. 2011 Oct 1;58(2):154-162. https://doi.org/10.1097/QAI.0b013e318229ba41
Byrd, Desiree A. ; Fellows, Robert P. ; Morgello, Susan ; Franklin, Donald ; Heaton, Robert K. ; Deutsch, Reena ; Atkinson, J. Hampton ; Clifford, David B. ; Collier, Ann C. ; Marra, Christina M. ; Gelman, Benjamin ; McCutchan, J. Allen ; Duarte, Nichole A. ; Simpson, David M. ; McArthur, Justin ; Grant, Igor. / Neurocognitive impact of substance use in HIV infection. In: Journal of Acquired Immune Deficiency Syndromes. 2011 ; Vol. 58, No. 2. pp. 154-162.
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