Neurocysticercosis

A natural human model of epileptogenesis

Theodore E. Nash, Siddhartha Mahanty, Jeffrey A. Loeb, William H. Theodore, Alon Friedman, Josemir W. Sander, Gagandeep Singh, Esper Cavalheiro, Oscar H. Del Brutto, Osvaldo M. Takayanagui, Agnes Fleury, Manuela Verastegui, Pierre Marie Preux, Silvia Montano, E. Javier Pretell, A. Clinton White, Armando E. Gonzales, Robert H. Gilman, Hector H. Garcia

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis. Methods A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis. Results Human neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis. Significance Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalEpilepsia
Volume56
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Neurocysticercosis
Seizures
Epilepsy
Granuloma
Edema
Parasites
Animal Models
Biomarkers
Education
Brain
Infection

Keywords

  • Epilepsy
  • Helminth
  • Seizure
  • Taenia solium

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Nash, T. E., Mahanty, S., Loeb, J. A., Theodore, W. H., Friedman, A., Sander, J. W., ... Garcia, H. H. (2015). Neurocysticercosis: A natural human model of epileptogenesis. Epilepsia, 56(2), 177-183. https://doi.org/10.1111/epi.12849

Neurocysticercosis : A natural human model of epileptogenesis. / Nash, Theodore E.; Mahanty, Siddhartha; Loeb, Jeffrey A.; Theodore, William H.; Friedman, Alon; Sander, Josemir W.; Singh, Gagandeep; Cavalheiro, Esper; Del Brutto, Oscar H.; Takayanagui, Osvaldo M.; Fleury, Agnes; Verastegui, Manuela; Preux, Pierre Marie; Montano, Silvia; Pretell, E. Javier; White, A. Clinton; Gonzales, Armando E.; Gilman, Robert H.; Garcia, Hector H.

In: Epilepsia, Vol. 56, No. 2, 01.02.2015, p. 177-183.

Research output: Contribution to journalArticle

Nash, TE, Mahanty, S, Loeb, JA, Theodore, WH, Friedman, A, Sander, JW, Singh, G, Cavalheiro, E, Del Brutto, OH, Takayanagui, OM, Fleury, A, Verastegui, M, Preux, PM, Montano, S, Pretell, EJ, White, AC, Gonzales, AE, Gilman, RH & Garcia, HH 2015, 'Neurocysticercosis: A natural human model of epileptogenesis', Epilepsia, vol. 56, no. 2, pp. 177-183. https://doi.org/10.1111/epi.12849
Nash TE, Mahanty S, Loeb JA, Theodore WH, Friedman A, Sander JW et al. Neurocysticercosis: A natural human model of epileptogenesis. Epilepsia. 2015 Feb 1;56(2):177-183. https://doi.org/10.1111/epi.12849
Nash, Theodore E. ; Mahanty, Siddhartha ; Loeb, Jeffrey A. ; Theodore, William H. ; Friedman, Alon ; Sander, Josemir W. ; Singh, Gagandeep ; Cavalheiro, Esper ; Del Brutto, Oscar H. ; Takayanagui, Osvaldo M. ; Fleury, Agnes ; Verastegui, Manuela ; Preux, Pierre Marie ; Montano, Silvia ; Pretell, E. Javier ; White, A. Clinton ; Gonzales, Armando E. ; Gilman, Robert H. ; Garcia, Hector H. / Neurocysticercosis : A natural human model of epileptogenesis. In: Epilepsia. 2015 ; Vol. 56, No. 2. pp. 177-183.
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