Neurocysticercosis in the HIV era: A case report and review of the literature

Jose A. Serpa, Ana Moran, Jerry C. Goodman, Thomas P. Giordano, A. Clinton White

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26 Scopus citations

Abstract

The prevalence of HIV is increasing in countries where neurocysticercosis is endemic. Co-infection rates are expected to rise; however, no systematic reviews of the subject are available. We performed a literature review of neurocysticercosis (NCC) occurring in HIV-infected patients and described the clinical and immunophenotypic characteristics of a NCC case presenting with probable immune reconstitution inflammatory syndrome. We identified 27 cases of NCC-HIV co-infection. The most frequent presentation (61%) was with multiple parenchymal lesions. Seven patients (30%) had other concomitant neurologic infections (e.g., tuberculosis, toxoplasmosis). Thirteen patients received cysticidal therapy, and 85% responded to therapy. Only three patients died (12%). Immunohistochemistry of brain tissue in our case revealed abundant CD3+, CD8+, and CD68+ cells. NCC should be included in the differential diagnosis of neurologic infections in HIV patients in endemic populations. Consideration of the patient's immune status should alert the clinician to potential atypical presentations.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume77
Issue number1
StatePublished - Jul 1 2007

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ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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