Neurodevelopmental influences on the immune system reflecting brain pathology

R. Ekman, R. Persson, C. L. Nilsson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A number of studies have shown that early life events can affect the development of the nervous system, contributing to particular individual differences in later vulnerability to different forms of psychosocial stress related to the environment and lifestyle. Neuropeptides, chemokines (CKs), neurotrophins (NTs) belong to the chemical microenvironment of the cells of the central nervous system (CNS). This paper reviews research performed in our and other laboratories indicating that mass spectrometry should play a significant role in future studies of the structures of proteins/peptides in neuroscience. These applications include peptide metabolism associated with normal and impaired neurone/immune function. Detailed information about peptide/protein processing in the CNS may be studied by using the lymphocyte as a model reflecting different chemical modifications of peptides/proteins related to various psychosomatic disturbances reflecting disorders of environment and lifestyle.

Original languageEnglish (US)
Pages (from-to)565-572
Number of pages8
JournalNeurotoxicity Research
Volume4
Issue number5-6
DOIs
StatePublished - Aug 2002
Externally publishedYes

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Keywords

  • Cell nucleus
  • Depression
  • Hypothalamus-pituitary-adrenal (HPA) axis
  • Lymphocyte
  • Schizophrenia
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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