Neurodevelopmental outcome in neonates after extracorporeal membrane oxygenation

Cranial magnetic resonance imaging and ultrasonography correlation

M. Pamela Griffin, Paul K. Minifee, Susan H. Landry, Patricia L. Allison, Leonard E. Swischuk, Joseph B. Zwischenberger

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Irreversible ligation of the right common carotid artery and right internal jugular vein is usual in venoarterial extracorporeal membrane oxygenation (ECMO) for treatment of severe respiratory failure in neonates. Vessel ligation with ECMO may magnify risksof cerebral hemorrhage or infarction (CHI) and adversely affect neurodevelopmental outcome. To correlate CHI after ECMO with neurodevelopmental outcome, we reviewed cranial ultrasonography (US) and magnetic resonance imaging (MRI) scans in 22 consecutive neonatal ECMO survivors and compared these with results of Bayley Scales of Infant Development obtained at 3, 6, 12, and 24 months of follow-up. All patients had US, and 19 had MRI. No US or MRI had focal abnormal findings attributable to ECMO; specifically, there was no evidence of CHI. Two infants had generalized cerebral atrophy, and one of these had an abnormal Bayley examination. One infant with a normal MRI had an single right focal seizure 4 days after ECMO. Of 20 infants with Bayley developmental tests at 3 to 30 months of age (mental index range, 72 to 135; motor index range, 71 to 150), only 3 were abnormal. In our experience, the incidence of CHI secondary to ECMO is less than that reported. After ECMO, the absence of intracranial hemorrhage, cerebral infarct, or cerebral atrophy on US or MRI usually correlates with normal short-term neurodevelopmental outcome.

Original languageEnglish (US)
Pages (from-to)33-35
Number of pages3
JournalJournal of Pediatric Surgery
Volume27
Issue number1
DOIs
StatePublished - 1992

Fingerprint

Extracorporeal Membrane Oxygenation
Ultrasonography
Magnetic Resonance Imaging
Newborn Infant
Cerebral Infarction
Cerebral Hemorrhage
Atrophy
Ligation
Intracranial Hemorrhages
Common Carotid Artery
Jugular Veins
Child Development
Respiratory Insufficiency
Survivors
Seizures
Incidence

Keywords

  • Extracorporeal membrane oxygenation (ECMO)
  • magnetic resonance imaging
  • neurodevelopmental outcome
  • ultrasonography

ASJC Scopus subject areas

  • Surgery

Cite this

Neurodevelopmental outcome in neonates after extracorporeal membrane oxygenation : Cranial magnetic resonance imaging and ultrasonography correlation. / Pamela Griffin, M.; Minifee, Paul K.; Landry, Susan H.; Allison, Patricia L.; Swischuk, Leonard E.; Zwischenberger, Joseph B.

In: Journal of Pediatric Surgery, Vol. 27, No. 1, 1992, p. 33-35.

Research output: Contribution to journalArticle

Pamela Griffin, M. ; Minifee, Paul K. ; Landry, Susan H. ; Allison, Patricia L. ; Swischuk, Leonard E. ; Zwischenberger, Joseph B. / Neurodevelopmental outcome in neonates after extracorporeal membrane oxygenation : Cranial magnetic resonance imaging and ultrasonography correlation. In: Journal of Pediatric Surgery. 1992 ; Vol. 27, No. 1. pp. 33-35.
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